固尔苏治疗新生儿重症胎粪吸入性肺炎的疗效观察

Curative Effect of Poractant Alfa on Severe Neonatal Meconium Aspiration Pneumonia

目的观察气管滴入肺表面活性物质(固尔苏)(PS)与常规方法治疗新生儿重症胎粪吸入综合征(MAS)的疗效对比。方法 64例粪吸入综合征患儿分为两组,对照组32例给予常规治疗,治疗组32例在常规治疗的基础上给予气管滴入固尔苏,对比观察两组疗效。结果治疗2、12、24 h后治疗组PaO2、PaO2/FiO2、a/APO2高于对照组,差异具有统计学意义(P<0.05)。结论气管滴入固尔苏治疗新生儿重症胎粪吸入性肺炎疗效显著。

Objective To observe curative effect comparison of poractant alfa （PS） and conventional method on severe neonatal meconium aspiration. Methods 64 cases neonatal with meconium aspiration were divided into two groups, control group （32 cases） was given conventional treatment, treatment group （32 cases） were given the poractant alfa by trachea drip, comparing curative effect of two groups. Results After 2, 12, 24 h of treatment, PaO2, PaO2/ FiO2, a/APO2 of treatment group is higher than the control group, the difference is statistically significant （P〈0.05）. Conclusion Poractant alfa by trachea drip in treatment of severe neonatal meconium aspiration pneumonia has a remarkable curative effect.