双格氏试剂法合成4,4’-二(二苯基膦基)联苯

Synthesis of 4,4'-bis(diphenylphosphine) biphenyl via di-Grignard reagent

以4-溴联苯为原料,通过卤代反应获得二溴联苯后,与活泼金属镁反应制备双格氏试剂,再与二苯基氯化磷反应一步合成目标化合物4,4’-二(二苯基膦基)联苯.采用核磁共振谱(1H、13C、31P NMR)、傅里叶变换红外光谱(FT-IR)、液质联用飞行时间质谱(LC-MS TOF)等对目标化合物进行表征,表征结果与结构相吻合.与传统的合成法相比,该法具有操作简便、反应条件温和、原料成本低等优点.

Organic disphosphine compounds have attracted great attention due to their unique properties.By halogenation with 4-bromobiphenyl,dibromobiphenyl was obtained and further reacted with magnesium to prepare di-Grignard reagent,then reacted with chlorodiphenylphosphine,the title compound 4,4＇-bis（diphenylphosphine） biphenyl was synthesized.And the structure of the title compound was characterized and confirmed by （1H, 13C and 31p） NMR, FT-IR and LC-MS TOF.Compared with traditional synthesis method, this method has advantages of simple operation, mild reaction condition and low material cost.