精神分裂症和精神病性抑郁症患者的感觉运动门控变化及临床症状观察

The observation of sensorimotor gating changes and clinical symptoms in schizophrenia and psychotic depression patients

目的研究感觉运动门控变化在精神分裂症和精神病性抑郁症患者中的对比及临床症状。方法选择2011年12月至2012年12月的精神分裂症患者48(A组),精神病性抑郁症患者53例(B组),健康检查的正常人50例(C组)。采用PPI及适应性评价患者感觉运动门控功能,统计患者惊跳反射及习惯化情况,并行汉密尔顿量表和阳性和阴性量表分评价。结果 A、B组患者的习惯化程度比较无明显统计学差异性(P>0.05),同时B组患者的惊跳反射指标要显著低于A组,且C组显著高于A组(P<0.05)。A、B两组患者的阳性、阴性以及一般病理分均无统计学差异(P>0.05),但A组的量表总分高于B组(P<0.05)。结论精神病性抑郁症患者的感觉运动门控损害情况较精神分裂症患者稍微严重,二者适应性反应比较一致,临床可通过阳性和阴性量表鉴别。

Objective To investigate sensorimotor gating changes and clinical symptoms in schizophrenia and psychotic depression patients. Methods 48 cases of schizophrenia patients from December 2011 to December 2012 were selected as group A , 53 psychotic depression patients as group B , 50 normal health examination patients as group C. Sensory gating channel function of all patients were weak stimulation and inhibition of startle reflex adaptability evaluation. Startle reflex and habituation cases of all patients were counted and three groups patients were scored by Hamilton Scale and the Positive and Negative Scale. Results The degree of habituation of group A and group B had no significant statistical difference （P〉0. 05）, at the same time the startle reflex index of patients in the group B was significantly lower than in A group, and C group was significantly higher than that of group A （P〈 0. 05）. Scores of positive, negative and general pathology of group A and group B were not statistically different, but total score of group A was higher than group B （P〈0. 05 ）. Conclusion Sensorimotor gating damage in psychotic depression patients is slightly more serious than the schizophrenic patients but their adaptive response are consistent. The negative and general pathology of schizophrenic patients is good way to analysis these two disease.