淋巴管生成相关因子在结直肠癌中的表达和作用

Expression and effect of related factors of lymphangiogenesis in colorectal cancer

结直肠癌淋巴转移严重影响其预后及生存，淋巴管生成在淋巴转移中发挥重要作用。近来研究发现 COX-2、MMP-7等因子可以促进 VEGF-C 的表达，而 VEGF-C 与其受体结合后激活相应信号通路可以促进淋巴管生成。目前，随着以上淋巴管生成相关因子在结直肠癌中被发现，结直肠癌淋巴管生成过程愈发清楚，但此类因子的确切作用机制尚待进一步研究。

The lymphatic metastasis affects prognosis and survival of colorectal cancer seriously,and lymphangiogenesis plays an important role in the lymphatic metastasis. Many factors such as COX-2 and MMP-7 which are found in many researches recently can promote the expression of VEGF-C which can promote the lymphangiogenesis by connecting with its receptor and activating the relevant signal pathway. At present,as these related factors of lymphangiogenesis are found in colorectal cancer,the process of lymphangiogenesis in colorectal cancer becomes more clear,but the exact mechanism of these factors needs to be researched in future.