一起家庭聚集性人感染H7N9禽流感事件的流行病学调查

Epidemiological investigation of a family clustering of human infection with avian influenza A( H7N9) virus

2014年2月浙江省东阳市一家庭发生2例儿童人感染H7N9禽流感病例,与病例发病相关的活禽外环境标本H7N9禽流感病毒核酸阳性率30%。为探索病例感染来源及判定是否存在人际传播,通过流行病学调查与暴露矩阵分析,认为病例A感染来源于暴露活禽,病例B感染来源于活禽暴露的可能性较大,但也不能完全排除人传人的可能性。

A household clustering of human infection with avian influenza A （H7N9） virus involving 2 children occurred in Dongyang in February 2014. The detections of related alive poultry samples and environmental samples indicated that positive rate of H7N9 virus nucleic acid detected was 30%. To identify the infection source and the possibility of person-to-person transmission, epidemiological investigation and exposure matrix analysis were conducted. The results showed that case A had alive poultry exposure history and case B might be exposed to alive poultry too, but the possibility of person to person transmission could not be ruled out.