系统性疾病相关ILD患者血清CEA水平与疾病严重程度及预后的相关性

Correlation of serum CEA levels with severity and survival of systemic disease-related interstitial lung disease(ILD)

目的研究血清癌胚抗原(CEA)在系统性疾病相关的间质性肺病(ILD)患者中的表达情况,及其与疾病严重程度及预后的相关性。方法收集80例系统性疾病相关ILD患者,并设立对照组,统计血清CEA水平,并将血清CEA水平与疾病严重程度指标进行Pearson相关分析,最后采用Kaplan-Meier生存分析及Cox回归分析评估血清CEA水平对1年生存率的影响。结果病例组血清CEA水平明显升高,血清CEA水平与ILD严重程度指标均相关,并与1年生存率显著相关(均P<0.05)。结论血清CEA水平是评估系统性疾病相关ILD病情及预后有较好相关性的血清学指标。

Objective To investigate the correlation of serum carcinoembryonic antigen （CEA） levels with the severity and survival of systematic disease-related interstitial lung disease （ILD）. Methods Serum CEA levels were measured by mi- croparticle enzyme immunoassays （Abbott kits and AxSYM system in 80 patients with ILD and 80 healthy subjects. Correlation of serum CEA levels with pulmonary function （DLco % and FVC% and OI） was evaluated by Pearson＇s correlation; that with fibrosis score on HRCT was analyzed by Spearman＇s correlation. Survival curve of patients was generated using Kaplan-Meier method, equality of survival distributions was tested using log-rank testing, univariate and multivariate Cox regression analyses. Results Serum CEA levels were higher in ILD patients than those in controls（P〈0.05）, were correlated with DLco%, FVC%, OI and fibrosis score on HRCT（P〈0.05）. Serum CEA levels were negatively correlated with 1-y survival of patients（P〈0.05）. Univariate and mul- tivariate Cox regression analysis demonstrated that serum CEA was an independent predictor of survival （HR=1.847, P=0.000）. Conclusion Serum CEA can be a cost-effective and convenient marker to evaluate disease severity, survival and prognosis of patients with systemic disease-related ILD.