人类半翼基因在宫颈癌、宫颈上皮内瘤变组织中的表达及其意义
摘要
宫颈癌是女性生殖系统最常见的恶性肿瘤之一。目前临床宫颈癌早期筛选的检测标记物主要有人乳头状病毒脱氧核糖核苷酸（HPV-DNA）和pl6INK4a，但都存在一定的局限性[1-5]，因此选择新的生物标记物来提高宫颈癌筛查的敏感度和特异度迫在眉睫。已有研究表明，正常宫颈、宫颈上皮内瘤变Ⅰ级（CINⅠ）、CINⅡ、CINⅢ和宫颈癌组织中,人类半翼基因（hWAPL）阳性表达率呈逐渐升高趋势，hWAPL与宫颈癌发生、发展有着密切关系。为探索hWAPL基因表达在宫颈上皮内病变筛查中的作用，我们研究了各级宫颈上皮内瘤变及宫颈癌组织中hWAPL的表达及其与宫颈细胞学结果之间的关系，现报道如下。
出处
《浙江医学》
CAS
2015年第12期1100-1102,共3页
Zhejiang Medical Journal
基金
浙江省公益技术研究社会发展项目(2012C33059)
参考文献7
-
1Shin E K, Lee S R, Kim M K, et al. Immunocytochemical staining of p16 (ink4a) protein as an adjunct test in equivocal liquid-based cytology [J]. Diagn Cytopathol, 2008, 36(5):311-316.
-
2Samama B, Schaeffer C, Boehm N. P16 expression in relation to human papillomavirus in liquid-based cervical smears[J]. Gy- necol Oncol, 2008, 109(2): 285-290.
-
3Benevolo M, Vocaturo A, Mottolese M, et al. Clinical role of p161- NK4a expression in liquid-based cervical cytology: correlation with HPV testing and histologic diagnosis[J]. Am J Clin Pathol, 2008, 129(4):606-612.
-
4Nassar A, O'Reilly K, Cohen C, et al. Comparison of p161NK4A and Hybrid Capture 2 human papillomavirus testing as adjunctive tests in liquid-based gynecologic SurePath preparations[J]. Di- agn Cytopathol, 2008,36(3): 142-148.
-
5Monsonego J, Pollini G, Evrard M J, et al. P16 (INK4a) immunocy- tochemistry in liquid-based cytology samples in equivocal Pap smears: added value in management of women with equivocal Pap smear[J]. Acta Cytol, 2007, 51(5):755-766.
-
6Oikawa K, Ohbayashi T, Kiyono T, et al. Expression of a novel hu- man gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression[J]. Cancer Res, 2004, 64( 10):3545-3549.
-
7鲁笑钦,崔金全,胡滨,邓克红,张庆,付美洲,王淑.宫颈癌组织中hWAPL蛋白的特异性表达[J].郑州大学学报（医学版）,2008,43(6):1156-1159. 被引量：2
二级参考文献13
-
1Verni F, Gandhi R,Goldberg ML, et al. Genetic and Molecular Analysis of wings apart-like (WAPL),a Gene Controlling Heterochromatin Organization in Drosophila melanogaster [ J ]. Genetics, 2000,154 ( 4 ) : 1 693
-
2Dobie KW, Kennedy CD, Velasco VM, et al. Identification of chromosome inheritance modifiers in drosophila melanogaster [ J ]. Genetics ,2001,157 ( 4 ) : 1 623
-
3Gandhi R, Gillespie PJ, Hirano T, et al. Human wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase[ J]. Curr Biol, 2006,16 ( 24 ) : 2 406
-
4Karan D, Chen SJ, Johansson SL, et al. Dysregulated expression of MIC21/PDF in human prostate tumor cells[ J]. Biochem Biophys Res Commun,2003,305 ( 3 ) : 598
-
5Bahaei S, Orhan D, Gogus C, et al. Thrombospondin21, vascular endothelial growth factor expression and microvessel density in renal cell carcinoma and their relationship with multifocality[J]. Eur Urol,2003,44( 1 ) :76
-
6Oikawa K, Ohbayashi T, Kiyono T, et al. Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis an tumor progression [J]. Cancer Res, 2004,64 ( 10 ) : 3 545
-
7Kuroda M,Oikawa K, Yoshida K, et al. Effects of 3-methylcholanthrene on the transcriptional activity and mRNA accumulation of the oncogene hWAPL [ J ]. Cancer Lett, 2005,221 (1) :21
-
8Kuroda M,Kiyono T, Oikawa K, et al. The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target[ J]. Br J Cancer,2005,92 (2) :290
-
9Adersson S,Rylander E, Larsson B, et al. The role of human papillomavirus in cervical adenocarcinonaa carcinogenesis[J]. Eur J Cancer, 2001,37(2) :246
-
10Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical caner[J]. N Engl J Med,2003,348(6) :518
-
1胡滨,崔金全,邓克红,石莹莹.宫颈癌组织高危型HPV感染与HWAPL蛋白表达的关系[J].郑州大学学报（医学版）,2014,49(6):862-865. 被引量：12
-
2王红,汤丽.HPV相关宫颈癌研究[J].中国优生与遗传杂志,2007,15(5):123-124.
-
3刘志宇,范治璐,张智勇,刘用楫,李霞.相关PSA在前列腺癌早期诊断中的作用[J].医师进修杂志（外科版）,2004,27(10):53-56.
-
4向晓娟,何友兼.弥漫大B细胞淋巴瘤survivin和caspase-3表达的临床意义[J].中华肿瘤杂志,2006,28(4):298-301. 被引量：6
-
5曾宪瑞,李英勇.p16^(INK4a)在妇科肿瘤中的研究进展[J].中国医疗前沿,2009,4(21):19-20. 被引量：1
-
6FU XI ZHAO,YA QIN MU,JUN CHENG GUO,RUN HUA LIU.Expression of Bcl-2 and Survivin in uterine cervical carcinogenesis and correlation between the expression and infection of HPV_(16/18)[J].Journal of Microbiology and Immunology,2005,3(4):246-253.
-
7鲁笑钦,崔金全,胡滨.hWAPL基因在宫颈癌组织中的特异性表达及意义[J].医药论坛杂志,2007,28(10):1-2. 被引量：3
-
8鲁笑钦,崔金全,胡滨,邓克红,张庆,付美洲,王淑.宫颈癌组织中hWAPL蛋白的特异性表达[J].郑州大学学报（医学版）,2008,43(6):1156-1159. 被引量：2
-
9李元昆,邓克红,崔金全.hWAPL基因多态性增加HPV16/18阳性宫颈癌患者的发病危险性[J].现代妇产科进展,2014,23(4):287-290. 被引量：2
-
10马晓洁,李莎莎,谭榜宪.宫颈癌淋巴结微转移的研究进展[J].现代妇产科进展,2015,24(4):303-305. 被引量：8
