中氮茚并喹啉酮类衍生物的体外抗菌活性研究

In vitro Antibacterial Activity of Indolizinoquinoline-5,12-dione Derivatives

目的:测试中氮茚并喹啉酮类衍生物的体外抗菌活性。方法:采用肉汤稀释法测试中氮茚并喹啉酮类衍生物对金黄色葡萄球菌金黄色亚种、解硫胺素芽孢杆菌、枯草芽孢杆菌、始旋链霉菌、耐甲氧西林金黄色葡萄球菌(MRSA)的抗菌活性。结果:中氮茚并喹啉酮类衍生物对金黄色葡萄球菌金黄色亚种、解硫胺素芽孢杆菌、枯草芽孢杆菌、始旋链霉菌有一定的抑制作用,尤其对MRSA具有较强的抑制作用,衍生物2a,2b,8a的MIC值(0.062 5μg·ml-1)仅为万古霉素(2.0μg·ml-1)的1/32。结论:中氮茚并喹啉酮类衍生物对多个菌种有抑制作用,对耐药菌MRSA抑制作用值得关注,其机制有待进一步研究。

Objective： To detect the in vitro antimicrobial activity of indolizinoquinoline-5,12-dione derivatives. Methods： Broth dilution method was used to test the in vitro antibacterial activity of indolizinoquinoline-5,12-dione derivatives against staphylococcus aureus staphylococcus subspecies, bacillus aneurinolytieus, bacillus subtilis, streptomyces pristinaespiralis and MRSA. Results ： Indolizino- quinoline-5,12-dione derivatives had an inhibitory effect against staphylococcus aureus staphylococcus subspecies, bacillus aneurinolytieus, bacillus subtilis and streptomyces pristinaespiralis. It had especially strong inhibitory effect on MRSA, and the MIC value （0.062 5μg·ml^-1 ） of derivative 2a, 2b and 8a was only 1/32 of that of vaneomycin （2.00 μg·ml^-1 ）. Conclusion： Indolizino- quinoline-5,12-dione derivatives have significant inhibitory effect against many strains, and the inhibitory effect against MRSA is worthy of attention and the mechanism should be studied further.