TOTAL SYNTHESIS OF CRYSTALLINE BOVINE INSULIN

We should like to communicate,as a result of our combined efforts for the past five years,this preliminary report on the total synthesis of crystalline bovine insulin,the structure of which was first elucidated by Sanger and coworkers[1]ten years ago.A number of papers on the synthetic work concerning insulin has been published during the past two years.Katsoyannis and coworkers[2,3].synthesized both the A and B chains of sheep insulin and,by combining them together according to the procedure of Dixon and Wardlow[4],observed only traces of insulin activity.Zahn,Meienhofer and co-

We should like to communicate, as a result of our combined efforts for the past five years, this preliminary report on the total synthesis of crystalline bovine insulin, the structure of which was first elucidated by Sanger and coworkers ten years ago.