3090例疑似手足口病患儿病毒血清学检测分析

Analysis of hand-foot-mouth disease in 3090 suspected children with serological detection

目的：对2014年宝鸡市手足口病患儿病原血清学进行调查,为制定手足口病防治措施提供科学依据。方法：采用ELISA法检测疑似HFMD患儿血清EV71Ig M、CA16Ig M、Echo Ig M,了解患儿病原血清学特征。结果：HFMD全年均有发病,4～11月为发病高峰期,致病以EV71为主,CA16检出率明显增高为18.75%（210/1120）,呈双重或多重感染占21.96%（246/1120）,以EV71Ig M阳性模式为主,且临床症状亦为重。结论：对疑似HFMD患儿应尽早检测血清抗体Ig M以明确病毒谱,利于临床诊治与防控。

Objective： To investigate the children with hand - foot - mouth disease in baoji city in 2014, in order to provide scientific basis for health sector to develop prevention and control measures of HFMD. Method： Using EL ISA method to detect EV71 IgM, CA16IgM and EchoIgM in children with serum, to know their pathogenic serological characteristics. Results： The data showed that the HFMD was happended throughout the year, the peak period of HFMD was 4- 11 month, pathogenesis was dominated by EVT1, the positive rate of CA16 was significantly increased 18.75% （210/1120）, double or multiple infection was accounted for 21.96 % （246/1120）, mainly dominated by positive EVTIlgM mode, and the clinical symptoms was heavy. Conclusion： It is necessary for suspected HFMD children to detect serum antibody of IgM early to clear virus spectrum, which will beneficial to clinical diagnosis and prevention.