南京市HIV感染者及艾滋病患者抗病毒治疗依从性及影响因素研究

Compliance of antiviral therapy and influencing factors in people living with HIV/AIDS in ;Nanjing

目的：了解南京市接受抗病毒治疗（ART）的HIV感染者及艾滋病患者（HIV/AIDS）的ART依从性及其影响因素，为提高HIV/AIDS人群的ART依从性提供参考。方法2014年5－6月在南京市第二医院接受免费高效抗反转录病毒治疗（HAART）的HIV/AIDS作为研究对象，收集一般人口学、ART情况及社会支持与歧视等信息，利用logistic回归分析HAART依从性的影响因素。结果共调查HIV/AIDS 276例，以依从性支持评价中心的依从性指数为评价标准，调查发现总体依从性良好252例，占91.3%。经单因素及多因素分析显示，提醒服药（OR＝0.13，95%CI：0.04～0.37）、年龄较大者（OR＝0.52，95%CI：0.31～0.89）服药依从性较好；而存在ART副作用（OR＝4.11，95%CI：1.35～12.56）、WHO分期较诊断时降低（OR＝3.56，95%CI：1.37～9.21）和吸烟（OR＝5.38，95%CI：2.00～14.45）是影响依从性的危险因素。结论南京市HIV/AIDS人群ART依从性整体情况较好，为进一步巩固提高，对存在ART副作用、无提醒服药、吸烟、年龄较小、病情减轻的患者加强服药依从性教育。

Objective To understand the compliance of highly active anti-retroviral therapy （HAART） and influencing factors in people living with HIV/AIDS （PLWHA） in Nanjing. Methods PLWHA receiving HAART in No. 2 Hospital of Nanjing during May-June 2014 were recruited in this study. Self-administrated questionnaire was used to collect the data about HAART compliance and socio-demographic characteristics of PLWHA surveyed. Descriptive and multivariate statistical analysis were conducted to examine the effects of the factors on self-reported HAART adherence. Results A total of 276 PLWHA were surveyed,According to the evaluation criterion of Center for Adherence Support Evaluation （CASE）,252 cases showed good compliance （91.3%）. logistic regression analysis revealed that smoking,progress of the disease and side effects,reminding of taking drug and age were correlated with self-reported HAART adherence. Conclusion It is suggested to strengthen the education about antiviral therapy compliance in PLWHA with mild infection and those who are smokers and young,suffer from side effects,have no reminding methods for taking drug.