期刊文献+

光遗传技术在可卡因成瘾机制中的应用 被引量:1

Advance in optogenetic application of cocaine addiction mechanisms
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摘要 目的 运用系统综述方法评价光遗传技术在可卡因成瘾机制中的应用.方法 以“光遗传技术”、“成瘾”、“可卡囚”等为关键词,通过检索中国期刊全文数据库、中国生物医学数据库、万方数字化全文期刊、维普全文数据库以及PubMed、SCIENCEDIRECT、SPRINGERLIN数据库,筛查符合纳入标准的文献,采用了定性系统综述.结果 分析纳入的文献后,结果显示:光遗传技术具有高空间及时间分辨率、低组织损伤等优势,其应用不仅证明了传统的中脑边缘多巴胺系统理论在可卡因成瘾机制中的重要作用,也弄清了相关核团之间的部分投射关系.关于多巴胺、谷氨酸等神经递质、突触重塑的分子机制研究也因此取得了飞速的进展.结论 光遗传技术的应用赋予了实验研究在探索成瘾涉及的神经回路和分子机制方面极大的潜力,为深入了解可卡因成瘾的机制开辟了新的路径,为成瘾的治疗方法开拓了广阔的前景。 Objective To integrate existing data and analyze the optogenetic application in the study of the cocaine addiction mechanism.Methods The key words "optogenetics","addiction"," cocaine" and so on were selected.Relevant research information was collected from various authentic databases such as China Journal Full-text Database,Chinese Biomedical Databases,Wanfang Digital Journals,VIP Full-text Database and PubMed,SCIENCEDIRECT,SPRINGERLINK databases by literature study,assess the quality of the studies and the qualitative systematic review was conducted in this study.Results Findings from present data showed that:with great spatial and temporal specificity,the optogenetic application not only proved the important role of traditional theories of mesolimbic dopamine system,but also dissected the neural circuits and molecular mechanisms of dopaminergic and glutamatergic neurotransmission underlying cocaine addiction.Conclusion The use of optogenetic tools has given researchers the potential to dissect the neuronal circuits and molecular changes,leading us to a better understanding of the mechanisms of cocaine addiction and to the development of novel treatment.
出处 《中华行为医学与脑科学杂志》 CAS CSCD 北大核心 2015年第6期573-576,共4页 Chinese Journal of Behavioral Medicine and Brain Science
基金 广东省自然科学基金项目(9251051500008)
关键词 光遗传技术 成瘾 光敏感蛋白 可卡因 Optogenetic Addiction Photosensitive proteins Cocaine
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参考文献40

  • 1Deisseroth K. Optogenetics[ J]. Nat Methods,2011,8( 1 ) :26-29.
  • 2Tye KM, Deisseroth K. Optogenetic investigation of neural circuits un- der/ying brain disease in animal models [J]. Nat Rev Neumsci, 2012, 13(4) :251-266.
  • 3Yizhar O, Fenno LE, Davidson TJ, et al. Optogenetics in neural sys-- terns [ J ]. Neuron, 2011,71 ( l ) : 9-34.
  • 4Zhang F,Wang LP, Brauner M, et at. Multimodal fast optical interro- gation of neural circuitry [ J]. Natm'e, 2007,446 ( 7136) : 633-639.
  • 5Zhang F, Prigge M, Beyrlere F, et al. Red-shifted optogenetic excita- tion: a tool for fast neural control derived from Volvox carteri[ J]. Nat Neurosci, 2008,11 (6) : 631-633.
  • 6Tourino C,Eban-Rothschild A,de Lecea L. Optogenetics in psychiat- ric diseases[J]. Curr Opin Neurobiol,2013,23(3) :430-435.
  • 7Self DW, Nestler EJ. Relapse to drug-seeking: neural and mlecular mechanisms [ J ]. Drug Alcohol Depend, 1998,51 (1-2) : 49-60.
  • 8Stefanik MT, Kupchik M, Brown IM, et al. Optogenetic evidence that pallidal projections, not nigral projections, from the nuelens ac- eumbenS coro are necessary for reinstating cocaine seekiug[ J ]. J Neu- rosci ,2013,33 (34) : 13654 -13662.
  • 9Wise RA. Ro]es for nigrostriatal---not just mesocorticolimbic--dopa- mine in reward and addiction [J]. Trerds Neuroscl, 2009,32 (10) : 517-524.
  • 10Chen BT,Yau H, Hatch C ,et al. Rescuing cocaine4nduced prefrontal cortex hypoactivity prevents compulsive cocaine seeking[ J]. Nature, 2013,496(7445) :359-362.

二级参考文献45

  • 1ZhouW,Liu H,Zhang F. Role of acetylcholine transmission in nucleus accumbens and ventral tegmental area in heroin-seeking induced by conditioned cues[J].Neuroscience,2007.1209-1218.
  • 2Williams M J,Adinoff B. The role of acetylcholine in cocaine addiction[J].Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,2008.1779-1797.
  • 3Oakman SA,Faris PL,Kerr PE. Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significandy from those projecting to ventral tegmental area[J].The Journal of Neuroscience,1995.5859-5869.
  • 4Olmstead MC,Munn EM,Franklin KB. Effects ofpedunculopontine tegmental nucleus lesions on responding for intravenous heroin under different schedules of reinforcement[J].The Journal of Neuroscience,1998.5035-5044.
  • 5Vertes RP,Linley SB. Comparison of projections of the dorsal and median raphe nuclei,with some functional considerations[J].International Congress Series,2007.98-120.
  • 6Hong EY,Lee HS. Retrograde study of projections from the tuberomammillary nucleus to the mesopontine cholinergic complex in the rat[J].Brain Research,2011.169-178.
  • 7Forster GL,Falcon AJ,Miller AD. Effects of laterodorsal tegmentum excitotoxic lesions on behavioral and dopamine responses evoked by morphine and d-amphetamine[J].Neuroscience,2002.817-823.
  • 8Schmidt HD,Famous KR,Pierce RC. The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT[J].European Journal of Neuroscience,2009.1358-1369.
  • 9Cid-Pellitero E,Garzón M. Hypocretinl/OrexinA axon targeting of laterodorsal tegrental nucleus neurons projecting to the rat medial prefrontal cortex[J].Cerebral Cortex,2011.2762-2773.
  • 10Ishibashi M,Leonard CS,Kohlmeier KA. Nicotinic activation of laterodorsal tegmental neurons:implications for addiction to nicotine[J].Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,2009.2529-2547.

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