获得性免疫缺陷综合征患者心理干预与临床疗效关系研究

Correlation between clinical effect and psychological intervention of patients with acquired immune deficiency syndrome

目的探讨个性化心理干预对获得性免疫缺陷综合征(AIDS)患者心理状况及免疫功能的影响。方法采用完全随机抽样方法将沈阳市第六人民医院2008年6月至2010年12月收治的符合纳入标准的195例抗病毒治疗AIDS患者随机分为干预组和对照组,两组样本量分别100例和95例,使用SCL-90量表对患者进行心理评测。对照组进行常规健康指导,干预组实施为期24个月的个性化心理干预措施。对完成本研究的195例AIDS患者,心理干预前后SCL-90量表各因子和CD4+T淋巴细胞数量的变化进行统计分析。结果心理干预后,SCL-90量表中的抑郁、焦虑、强迫、敌对性、阳性总分因子分数下降程度大于对照组,干预12个月、24个月CD4+T淋巴细胞计数升高程度大于对照组(P<0.05)。结论心理干预可以在一定程度上减轻AIDS抗病毒治疗患者的某些负性情绪,提高患者免疫功能,并且随着干预时间的增加效果越好。

Objective To evaluate the effect of psychological intervention on the mental state and immune function of patients with acquired immune deficiency syndrome （AIDS）. Methods A total of 195 AIDS patients treated with highly active antiretroviral therapy （HAART） were randomly divided into two groups containing 100 and 95 patients, respectively. We used Symptom Checklist 90 self assessment （SCL-90） to evaluate AIDS patients. Patients in the control group received routine care, while their counterparts in the intervention group received individualized psychological care. The intervention lasted 24 months. Statistical analysis of SCL- 90 each factors and CD4＋T lymphocytes quantity changes for the 195 cases was taken before and after psychological intervention. Results After psychological intervention, depression, anxiety, the obsessive-compulsive, hostility, and general symptomatic index declined significantly （P〈0.05）, while CD4＋T lymphocytes increased significantly as compared with those in the control group （P〈 0.05）. Conclusion Psychological intervention can alleviate negative emotions of AIDS patients receiving HA_ART, and improve their immune function.