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海洋来源普通青霉菌(Penicillium commune 366606)的化学成分研究

Study on the chemical constituents of Penicillium commune 366606 from marine fungus
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摘要 研究海洋来源普通青霉菌Penicillium commune 366606的化学成分.人工海水发酵,发酵产物通过乙酸乙酯萃取后得浸膏,运用硅胶柱色谱、凝胶柱色谱（Sephadex LH-20）和反相RP-18柱色谱进行分离纯化.运用现代波谱学方法（NMR、MS）和结合文献数据等对分离所得化合物的结构进行鉴定.从海洋真菌发酵液中分离得到7个化合物,结构分别鉴定为melithasterol B（1）、chrysophanol（2）、2’,3’-dihydrosorbicllin（3）、2-pyruvoybenzamide（4）、2-aceylquinazolin-4（3H）-one（5）、fenestins A（6）、cyclo（D-Pro-D-Leu）（7）.所有化合物均为首次从普通青霉菌（Penicillium commune 366606）中分离得到,并报道了化合物4~7对5株癌细胞活性研究. The chemical constituents of Penicillium commune 366606 were studied. The compounds were isolated by silica column chromatography,Sephadex LH- 20 column chromatography and RP- 18 reverse- phase column chromatography respectively. The structures were elucidated on the basis of spectral characteristics and compared with the data of literatures. From the ethyl acetate extracts of Penicillium commune 366606,seven compounds were isolated and identified as melithasterol B（ 1）,chrysophanol（ 2）,2＇,3＇- dihydrosorbicllin（ 3）,2-pyruvoybenzamide（ 4）,2- aceylquinazolin- 4（ 3H）- one（ 5）,fenestins A（ 6）,cyclo（ D- Pro- D- Leu）（ 7）. All compounds were obtained from Penicillium commune 366606 for the first time. Compounds 4—7 showed inactive against K562,A549,HL- 60,SMMC- 7721,MCF- 7 and SW- 480.
作者 何江波 李兆桥 贾静 陶剑 张雪梅 缪希松 何方 句红萍
机构地区 昆明学院医学院 即墨市人民医院
出处 《云南大学学报（自然科学版）》 CAS CSCD 北大核心 2015年第4期564-568,共5页 Journal of Yunnan University(Natural Sciences Edition)
基金 昆明学院博士基金启动项目(YJL14009)
关键词 普通青霉菌 生物碱 化学成分 Penicillium commune 366606 alkaloid chemical constituents
分类号 Q936 [生物学—微生物学]
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参考文献12

  • 1HILL R T, FENICAL W.Pharmaceuticals from marine natural products : Surge or ebb? [ J ]. Curt Opin Biotechnol, 2010,21 : 777-779.
  • 2MOLINSKI T F, DALISAY D S, LIEVENS S L, et al. Drug development from marine natural prodycts [ J ]. Nat Rev Drug Dis- covery, 2009,8 : 69-85.
  • 3BURKHOLDER P R, PFISTER R M, LEITZ F H.Production of a pryrole antibiotic by a marine bacterium [ J] .Appl Microbi- ol, 1966,14:649-653.
  • 4MOSTAFA E R, RAINER E.Secondary metabolites of fungi from marine habitats [ J ] .Nat Prod Rep, 2011,28:290-344.
  • 5JOHN W B, BRENT R C, MURRAY H G M, et al. Marine natural products [ J ] .Nat Prod Rep, 2011,28 : 196-268.
  • 6黄孝春,刘海利,郭跃伟.南海蓖麻海绵Biemna fortis Topsent化学成分及其生物活性[J].中国天然药物,2008,6(5):348-353. 被引量：8
  • 7杨淑敏,刘锡葵,卿晨,吴大刚,朱大元.水杨柳根的化学成分(英文)[J].药学学报,2007,42(3):292-296. 被引量：21
  • 8MASKEY R, GRUN-WOLLNY I, LAATSCH H.SorbiciUin analogues and related dimeric compounds from PeniciUium notatum [J].J Nat Prod,2005,68(6):865-70.
  • 9TEZUKA Y, HUANG Q, KIKUCHI T, et al. Studies on the metabolites of mycoparasitic fungi. I. metabolites of Cladobotryum varium[ J] .Chem Pharm Bull, 1994,42(12) :2 612-2 617.
  • 10DYAKONOV A L, TELEZHENTSKAYA M V. Quinazoline alkaloids in nature [ J ]. Chem Nat Compd, 1997,33 ( 3 ) : 221-267.

二级参考文献15

  • 1Wu ZY,Zhou TY,Xiao PG.New China Compendium of Materia Medica:Vol.2 (新华本草纲要:第二册)[M].Shanghai:Shanghai Science and Technology Press,1991:224.
  • 2Parver N,Pal Singh M,Khan NU.Chemical examination of the leaves of Homonoia riparia Lour.(Euphorbiaceae)[J].J Indian Chem Soc,1988:815-816.
  • 3Chaudhuri SK,Fullas F,Brown DM,et al.Isolation and structural elucidation of pentacyclic triterpenoids from Maprounea Africana[J].J Nat Prod,1995,58:1-9.
  • 4Niu XM,Li SH,Li ML,et al.Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var.laxiflora[J].Planta Med,2002,68:528-533.
  • 5Mclean S,Perpick-Dumont M,Reynolds WF,et al.Unambiguous structural and nuclear magnetic resonance spectral characterization of two triterpenoids of maprounea guianensis by two-dimensional nuclear magnetic tesonance spectroscopy[J].Can J Chem,1987,65:2519-2525.
  • 6Sakurai N,Yaguchi Y,Inoue T.Triterpenoids from Phyllanthus niruri[J].Phytochemistry,1987,26:217-219.
  • 7Mahato SM,Kundu AP.^13C NMR spectra of pentacyclic triterpenenoids-A compilation and some salient features[J].Phytochemistry,1994,37:1517-1575.
  • 8Kojima H,Oguraa H.Triterpenoids from Peunella vulgaris[J].Phytochemistry,1986,25:729-733.
  • 9Reynolds WF,McLean S,Enriquez JPR,et al.Total assignment of ^13C and ^1H spectral of three isomeric triterpenol derivatives by 2D NMR:an investigation of the potential utility of ^1H chemical shifts in structure investigation of complex natural products[J].Tetrahedron,1986,43:3419-3428.
  • 10Sholichin M,Yamasaki K,Kasai R.^13C nuclear magnetic resonance of lupane-type triterpenes,lupeol,betulin and betulinic acid[J].Chem Pharm Bull,1980,28:1006-1008.

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云南大学学报（自然科学版）
2015年 第4期

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