组蛋白脱乙酰化酶抑制剂抗心脏纤维化作用及免疫机制

Anti-cardiac fibrosis effect and immunologic mechanism of histone deacetylases inhibitors

可逆性组蛋白乙酰化在调节心肌纤维化过程中具有核心作用，而组蛋白乙酰基转移酶（HATs）和组蛋白脱乙酰化酶（HDACs）是决定组蛋白乙酰化程度的两种主要酶。组蛋白脱乙酰酶抑制剂（HDACIs）具有抗纤维化作用，可减少心脏细胞凋亡、肥大以及心室纤维化，其抗心脏纤维化作用与其对心脏成纤维细胞、肾素一血管紧张素一醛固酮系统及其免疫机制密切相关。不久的未来，HDAC抑制剂可能作为一种新型的治疗心衰的药物。

The reversible histone acetylation plays a crucial role in regulating myocardial fibrosis. His- tone acetyl transferase （HATs） and histone acetylation enzyme （HDACs） are two key enzymes which determine the leve｜ of histone acetylation. Histone deacetylases inhibitors, HDACIs show anti-cardiac fibrosis effect due to their inhibition on cardiac fibroblasts or renin-angiotensin-aldosterone system. HDACIs can reduce myocardial apoptosis, myocardial hypertrophy and myocardial fibrosis. In the future, HDAC inhibitor may be employed as a novel drug in the treatment of heart failure.