帕金森病的神经保护治疗

The neuroprotection of Parkinson＇s disease

帕金森病是一种常见的中枢神经系统变性疾病，其神经退变进行性加重，会导致患者严重残疾，寿命缩短，目前尚无有效的预防和根治措施。大量研究表明，帕金森病的发病机制涉及到线粒体功能和氧化应激，免疫反应，营养因子缺乏，细胞凋亡，蛋白质异常表达等。神经保护治疗能够延缓或终止帕金森病的进展，预防残疾的进一步加重。

Parkinson＇ s disease is a common neurodegenerative disorder. In Parkinson＇ s disease, neu- rodegeneration is progressive and leads to severe disability and life expectancy. There is no effective preventative or curative therapies at present. Substantial evidence supports the involvement of mitochondrial dysfunction and oxidative stress, inflammation,lack of trophic factors, apoptosis, and changed protein handling in the pathogenesis of Parkinson＇ s disease, Neuroprotective therapy can slow or stop the disease progression and prevent the development of cumulative disability. We will troduce several promising targets and neuroprotective therapies for the neurodegeneration of Parkinson＇ s disease.