疏水改性聚磺酸甜菜碱的合成及其结构研究

Synthesis and Structure of Hydrophobically Modified Polysulfobetaine Methacrylate

疏水改性聚磺酸甜菜碱具有超亲水、抗蛋白吸附、环境友好等性能,在药物缓释、化妆品、器官移植、食品包装等领域潜在应用价值巨大。采用自由基胶束共聚法合成了具有疏水嵌段的聚磺酸甜菜碱共聚物,亲水单体为[2-(甲基丙烯酰基氧基)乙基]二甲基-(3-磺酸丙基)氢氧化铵(SBMA),疏水单体为甲基丙烯酸缩水甘油酯(GMA),探究了聚合条件对共聚物结构及性质的影响。研究发现,引发剂用量较高时,SBMA的含量相对较高。当GMA用量较少时,SBMA含量随乳化剂用量的增加而下降;当GMA用量较大时,乳化剂用量对共聚物中SBMA含量影响不显著。搅拌速率增加后,共聚物水溶液的表观粘度(ηa)和SBMA含量均逐渐下降。GMA用量增大后,疏水嵌段长度及数量均增大。相同单体投料比下,乳化剂用量越大,形成的GMA胶束数量越多,共聚后形成的疏水嵌段长度越短,数量越多。P(SBMA-GMA)大分子在水中以胶束形式存在。自由基胶束聚合得到的P(SBMA-GMA)共聚物的分子量高于SBMA均聚物。以上研究结果可为疏水改性聚两性电解质的制备工艺优化提供参考。

Hydrophobically modified polysulfobetaines exhibit superhydrophilicity, anti-protein adsorption and are environmentally friendly, which have potential applications in drug delivery, cosmetic, organ transplantation, food packaging and so on. In this work, polysulfobetaine methacrylate (PSBMA) hydrophobically modified with methacrylic acid 2,3-epoxypropyl ester (GMA) was synthesized via a free radical micellar copolymerization method. Effect of reaction condition upon the properties of the copolymer such as apparent viscosity of the copolymer aqueous solution and the yield were investigated. Experimental results showed that the content of SBMA was higher as the content of initiator was increased. When GMA content was low, the amount of SBMA decreased with increasing surfactant amount. However, the amount of SBMA was slightly influenced by the amount of surfactant in the case of high content GMA. Both the viscosity of the copolymer aqueous solution and the SBMA content decreased with the increase of stirring speed. The length and content of hydrophobic block segments were enlarged as GMA content was increased. Under the same ratio of SBMA/GMA monomers, increasing the amount of emulsifier increased the amount of GMA micelle and the content of hydrophobic block in copolymer. P(SBMA-GMA) copolymer chains were in the form of micelles in water, and the number molecular weight of P(SBMA-GMA) was higher than that of PSBMA.