湖北襄阳地区女性宫颈高危型HPV感染分布情况及危险因素探讨

Investigation on the infection distribution and risk factors of high-risk type HPV in women cervix in Xiangyang, Hubei province

目的 分析高危型人乳头瘤病毒（human papillomaviruses,HPV）在湖北襄阳地区妇女中的感染率及感染年龄分布情况,以及危险因素.方法 以2012-2014年间在本院就诊的4689例患者为研究对象,采用cervista酶切信号放大法检测14种高危型的HPV.其中感染高危型HPV阳性病例则进一步分析HPV感染年龄分布情况以及其在子宫颈上皮非典型增生（CIN）、宫颈癌、宫颈炎患者中的感染情况,并结合病例资料分析HPV感染危险因素.结果 4689例患者中有950例感染高危型HPV,感染率为20.26％.HPV在宫颈癌患者中的感染率最高,其次为CIN,宫颈癌相较于其他两类患者感染率对比差异有统计学意义（P＜0.05）.HPV以≥55岁者的感染率最高.初次性行为年龄过早、宫颈癌家族史、多产史、经常熬夜等均是HPV感染的影响因素.结论 湖北襄阳地区HPV感染率与LARC国际癌症研究协会公布的亚洲常见HPV感染率一致.在不同年龄段中,感染率最高的年龄组为55岁以上及25岁以下,宫颈癌、CIN患者HPV感染率较高,而经常熬夜、有宫颈癌家族史、初次性行为年龄过早等因素属于HPV感染危险因素.

Objective To investigate the infection rate and age distribution of high-risk type HPV in Xiangyang,Hubei province,and analyze the related infection factors.Methods 4689 patients were collected as research subjects in our hospital from 2012 to 2014.Cervista HPV HR DNA test was used to detect the high-risk type HPV.For positive samples,the distraction of infection age and infection rate in CIN,cervical cancer and cervicitis were analyzed and the infection risk factors of HPV in these patients were analyzed.Results 950 cases in 4689 patients were infected with high-risk type HPV and the infection rate was 20.26%.The patients with cervical cancer had the highest HPV infection rate,followed by CIN.There was significant differences between cervical cancer patients and the other two types of patients （P 〈 0.05）.Patients above 55 years old had the highest infection rate.Early sexual behavior,family history of cervical cancer,prolificacy history,and staying up late were all the risk factors of HPV infection.Conclusions The infection rate of HPV in Hubei xiangyang area was consistent with that in Asia released by the international association for cancer research （LARC）.Women above 55 and below 25 years old had higher infection rate.The cervical cancer patient and CIN patient had higher infection rate.Staying up late,family history of cervical cancer,and early sexual behavior were the risk factors of HPV infection.