血浆ADMA水平与急性脑梗死病灶大小及神经功能缺损程度的相关性研究被引量：5

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摘要目的:探讨血浆非对称性二甲基精氨酸(ADMA)与急性脑梗死患者病灶大小及神经功能缺损程度之间的关系。方法:将本院160例急性脑梗死病例,根据病灶大小分为腔梗组、小面积梗死组、中等面积梗死组、大面积梗死组4个观察组,每组各40例,参照美国国立卫生研究所卒中量表(NISS)评估神经功能缺损程度;选择同期健康体检者40例作为对照组。采用高效液相色谱联合质普法(HPLC)检测其血浆ADMA浓度,比较各组间血浆ADMA水平,分析血浆ADMA水平与病灶大小及神经功能缺损程度是否存在相关性。结果:4个不同梗死面积急性脑梗组及对照组血浆ADMA水平分别为(0.57±0.23)umo L/L、(0.79±0.21)umo L/L、(0.93±0.23)umo L/L、(1.12±0.25)umo L/L、(0.32±0.19)umo L/L,组间多重比较差异均有统计学意义(P<0.05);经spearman相关分析提示:血浆ADMA水平与病灶大小及神经功能缺损程度均存在正相关,差异经统计具有统计学意义(P<0.05)。结论:与健康者比较急性脑梗死患者血浆非对称性二甲基精氨酸水平较之均有不同程度升高,并与患者的梗死病灶大小以及其神经功能缺损程度存在正相关。

作者余蕾黄觅

机构地区湖北省武汉市第十一医院

出处《河北医学》 CAS 2015年第11期1765-1768,共4页 Hebei Medicine

基金国家自然科学基金 (编号:Q2007A03)

关键词脑梗死非对称性二甲基精氨酸 ADMA 病灶大小神经功能缺损

分类号 R743.3 [医药卫生—神经病学与精神病学]

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1吴兆苏,姚崇华,赵冬.我国人群脑卒中发病率、死亡率的流行病学研究[J].中华流行病学杂志,2003,24(3):236-239. 被引量：719
2Sibal L, Agarwal SC, Home PD, et al. The role of asymmetric dimethyllarginine (ADMA)in endothelial dysfunction and cardiovascular disease [ J ]. Curr Cardiol Rev, 2010,6 (2) : 82 -90.
3Worthmann H, Chen S, Martens Lobenhoffer J, et al. High plasma dimethylarginine levels are associated with adverse clinical outcome after stroke [ J ]. Atheroscler Thromb, 2011, 18(9) :753-761.
4各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33022
5刘俊,王洪巨.非对称性二甲基精氨酸生物学特性[J].岭南心血管病杂志,2007,13(4):302-304. 被引量：6
6Chen S, Li N, Deb Chatter ji M, et al.Asymmetric dimethya- rginine as marker and mediator in ischemic stroke [ J ]. Int Mol Sei, 2012,13 : 15983 - 16004.
7Blackwell S. The biochemistry, measurement and current clinical significance of asymmetric dimethlarginine [ J ]. Ann Clin Biochem, 2010,47( 1 ) : 17 - 28.
8De Gennaro Colonna V, Bonomo S, Ferrario P, et al. Asym- metric dimethylarginine (ADMA) induces vascular endo- thelium impairment and aggravates postisehemic ventrieular dysfunction in rats [ J ]. Eur Pharmacol, 2007,557 ( 2 - 3 ) : 178- 185.
9刘艳丽,冯敏,李青,肖益群,陈锦屏.急性脑梗死患者血浆ADMA与同型半胱氨酸水平相关性研究[J].中国现代药物应用,2011,5(19):41-42. 被引量：2

二级参考文献24

1Toth J, Racz A, Kaminski PM, et al. Asymmetrical dim ethylargi- nine inhibits shear stress-induced nitric oxide release and dilation and elicits superoxide-mediated increase in arteriolar tonel. Hyper- tension,2007,49 (3) :563-568.
2de Gennaro Colonna V,Bonomo S,Ferrario P, et al. Asym metric dimethylarginine (ADMA) induces vascular endothelium impairm ent and aggravates post-ischemic ventricular dysfunction in ratsl. Eur J Phannaco1,2007,557 ( 2-3 ) : 178-185.
3B(O)GER RH,BODE-BOGER SM,SZUBA A,et al.Asymmetric dimethylarginine (ADMA):a novel risk factor for endothelial dysfunction:its role in hypercholesterolaemia[J].Circulation,1998,98(18):1842-1847.
4BOISVERT FM,COTE J,BOULANGER MC,et al.A proteomic analysis of arginine-methylated protein complexes[J].Mol Cell Proteomics,2003,2(12):1319-1330.
5WADA K,INOUE K,HAGIWARA M.Identification of methylated proteins by protein arginine N-methyltransferasel (PRMT1)with a new expression cloning strategy[J].Biochim Biophys Acta,2002,15919 (1-3):1-10.
6B(O)GER RH,SYDOW K,BORLAK J,et al.LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells:involvement of S-adenosylmethionine dependent methyltransferases[J].Circ Res,2000,87 (2):99 -105.
7MACALLISTER RJ,PARRY H,KIMOTO M,et al.Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase[ J].Br J Pharmacol,1996,119 (8),1533-1540.
8CARDOUNEL AJ,XIA Y,ZWEIER JL.Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase:differences in the effects of monomethyl-and dimethylarginines in the presence and absence of tetrahydrobiopterin[J].J Biol Chem,2005,280 (9),7540-7549.
9BRUNINI T,MOSS M,SIQUEIRA M,et al.Inhibition of L-arginine transport in platelets by asymmetric dimethylarginine and N-monomethyl-L-arginine:effects of arterial hypertension[J].Clin Exp Pharmacol Physiol,2004,31 (10):738-740.
10SUDA O,TSUTSUI M,MORISHITA T,et al.Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice:involvement of reninangiotensin system and oxidative stress[J].Arterioscler Thromb Vasc Biol,2004,24(9):1682-1688.