米氮平与舍曲林治疗阿尔茨海默病伴发的抑郁对照研究

Comparative Study between Mirtazapine and Amitriptyline in Treatment of Depression Induced by Alzheimer Disease

目的:对比米氮平治疗阿尔茨海默病伴发的抑郁与舍曲林治疗的效果。方法:收集267例阿尔茨海默病伴发的抑郁患者随机分为3组,每组89例,分别为米氮平组、舍曲林组和安慰剂组,治疗周期为8周,采用康奈尔痴呆抑郁量表(CSDD量表)和Hamiltion抑郁量表(HAMD)评定临床效果。结果:舍曲林组、米氮平组与安慰剂组相比,治疗后2周的CSDD评分和HAMD评分差异均无统计学意义;治疗后4周和8周CSDD评分和HAMD评分较治疗前均有显著下降(P<0.05),两组间比较米氮平组CSDD评分和HAMD评分均较舍曲林组有显著差异(P均<0.05)。结论:米氮平治疗老年血管性痴呆伴抑郁有效,与舍曲林对比疗效相当,但副作用更少。

Objective： To evaluate the efficacy of mirtazapine and sertraline on depression Induced by alzheimer disease. Method ：267 cases of elderly patients of dementia with depression in our hospital outpatient,they were randomly divided into three groups, the mirtazapine group （ 89 cases） , sertraline group （89 cases） and control group （ 89 cases） for a period of eight weeks, using HAMD, CSDD rating scale to evaluate clinical effects. Result： There were significant difference between mirtazapine group, sertraline group and control group HAMD and CSDD scores. Mirtazapine incidence of side effects, was higher than that of sertraline group. Conclusion：It is suitable for the elderly patients that mirtazapine and sertraline have the equivalent therapeutic effects in the treatment of geriatric depression.