硫酸镁联合硝苯地平控释片治疗妊高征临床分析

Magnesium Sulfate in Combination with Nifedipine Controlled Release Tablets in Treatment of Pregnancy-induced Hypertension

目的:分析硫酸镁联合硝苯地平控释片治疗妊高征的临床疗效。方法:将我院收治的78例妊高征患者随机分为观察组39例和对照组39例。观察组患者在常规治疗的基础上行硫酸镁联合硝苯地平控释片治疗,对照组患者在常规治疗的基础上行单纯的硫酸镁治疗。评价两组患者的临床治疗效果,监测患者治疗前后的相关生化指标,并对母婴预后进行随访观察。结果:治疗后,观察组患者的SBP、DBP指标值均低于对照组(P均<0.05),尿蛋白减少率高于对照组(P<0.05),且患者的BUN、UA、Cys C指标值均低于对照组(P均<0.05)。同时,观察组患者母婴死亡率及提早终止妊娠、子痫、胎盘早剥、子宫过度收缩等并发症的总发生率为12.81%,对照组为25.65%,两组比较,差异具有统计学意义(P<0.05)。结论:硫酸镁联合硝苯地平控释片治疗妊高征的临床疗效要优于单纯的硫酸镁治疗,能有效改善患者血压、肾功能及母婴预后。

Objective： To analyse curative effect magnesium sulfate in combination with nifedipine controlled release tablets clinical on pregnancy-induced hypertension. Method： 78 cases patients were divided into observation group （39 cases） and control group （39 cases）. On the basis of routine therapy, patients of observation group were treated by magnesium sulfate with ifedipine controlled release tablets, the control group patients were treated by magnesium sulfate. Effect of patients between two groups was assessed, related biochemical indexes was monitored, maternal and infant prognosis was observed. Result： After treatment, SBP, DBP, parameter values the patients observation group were lower than the control group （ P 〈 0.05 ） , urinary protein loss was higher than the control group （P 〈 0.05） , and the patient＇s BUN, UA, CysC parameter values were lower than the control group （ P 〈 0.05）. At the same time, the patients group of observation with maternal and infant mortality, early termination of pregnancy, preeclampsia, placental abruption, uterine the total incidence of complications such as excessive contraction was 12.81%, the control group was 25.65% ,There＇s statistically significant difference （ P 〈 0.05 ）. Conclusion： Magnesium sulfate combined with nifedipine retard-20 tablet high stretch marks of clinical curative effect is superior to pure magnesium sulfate, can effectively improve blood pressure, renal function and prognosis of the patients.