基于数据挖掘的国医大师颜正华含当归处方用药规律研究

Analysis on the medication rules of state medical master Yan Zhenghua from the prescriptions with Angelicae Sinensis Radix based on data mining

目的：通过收集颜正华教授2000－2009年北京中医药大学国医堂出诊处方，分析含当归处方的用药规律。方法在收集处方的基础上，基于中医传承辅助平台（V2.0.1）构建数据库，使用软件的统计报表模块、数据分析模块，关联规则apriori算法等数据挖掘方法，分析含当归处方中单味药物频次、药物组合频次、关联规则与核心药物组合等。结果含当归处方常用于治疗胃痛、痹证、月经不调等病证，高频次药物包括赤芍、白芍、丹参、陈皮、香附等，高频次药物组合包括“当归，赤芍”“白芍，当归”“丹参，当归”等，置信度≥0.9的关联规则包括“大枣-当归”“砂仁-当归”“党参-当归”“龙骨-牡蛎”等。结论颜正华教授含当归处方所用药物多具补血活血、理气调经等功效，用药较为集中，组方法度清晰。

Objective To explore the medication rules of State Medical MasterYan Zhenghua. Methods The prescriptions including Angelicae Sinensis Radix that built by Pro. Yan were collected to build a database based on Traditional Chinese Medicine （TCM） inheritance assist system（V2.0.1）. After analyzed by the statistical reports module and the data analysis module which were from TCM inheritance assist system, and the methods of data-mining that including association rules and apriori algorithm, the frequency of single medicine, the frequency of drug combination, the association rules between drugs and core drug combinations which all were including Angelicae Sinensis Radix can be get from the database.Results The prescriptions including Angelicae Sinensis Radix were commonly used to treat stomach-ache, arthralgia syndrome, irregular menstruation and other syndromes. The highest frequency used drugs were Radix Paeoniae Rubra, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, and so on. The most frequency drug combinations were “Angelicae Sinensis Radix, Radix Paeoniae Rubra”, “Radix Paeoniae Alba, Angelicae Sinensis Radix”, and “Radix Salviae Miltiorrhizae, Angelicae Sinensis Radix”. The drug association rules that the confidence was more than 0.9 were “Fructus Jujubae-Angelicae Sinensis Radix”, “Fructus Amomi Villosi-Angelicae Sinensis Radix”, “Radix Codonopsis-Angelicae Sinensis Radix”, and “Os Draconis-Concha Ostreae”, and so on.Conclusion The drugs in the prescriptions containing Angelicae Sinensis Radix that built by Pro. Yan mostly had the effects of cooling blood, replenishing blood, and promoting blood circulation for removing blood stasis, which reflected the clear thought when making prescriptions.