支气管哮喘患儿血清炎性因子水平与氧化应激状态评估

Assessment of serum inflammatory cytokines and oxidative stress in asthma children

目的探讨支气管哮喘患儿血清氧化应激状态与炎性因子水平及相互关系。方法选择支气管哮喘患儿97例作为观察组,其中发作期及缓解期分别有53例、44例。对照组选择健康儿童50例,分别检测两组儿童MCP-1、MDC、Hs-CRP及MDA、SOD、GSH。结果观察组缓解期患儿MCP-1、MDC、Hs-CRP较发作期均有显著性下降(P<0.05),对照组MCP-1、MDC、Hs-CRP较发作期及缓解期患儿均有显著性下降(P<0.05)。观察组缓解期患儿SOD及GSH较发作期均有显著性升高(P<0.05),MDA显著下降(P<0.05)。对照组SOD及GSH较发作期及缓解期均有显著性升高(P<0.05),MDA较发作期有显著性下降(P<0.05)。MCP-1与MDA、SOD、GSH呈显著相关(P<0.05),MDC与SOD、GSH呈显著负相关(P<0.05),Hs-CRP与MDA、SOD、GSH未见显著相关性(P>0.05)。结论支气管哮喘患儿炎性因子水平失衡与氧化应激状态密切相关,是参与支气管哮喘发病过程的重要因素。

Objective To investigate serum inflammatory cytokines and oxidative stress in asthma children.Methods 97 cases of children with bronchial asthma were selected as the observation group,including exacerbation and remission（53 cases,44 cases）.50 healthy children were choosen as the control group,MCP-1,MDC,Hs-CRP and MDA,SOD,GSH were detected.Results MCP-1,MDC,Hs-CRP in observation group with remission significantly decreased（P〈0.05）,MCP-1,MDC,Hs-CRP of the control group compared with exacerbation and remission showed significant decrease（P〈0.05）.SOD and GSH of remission patients compared with exacerbation significantly increased（P〈0.05）,MDA decreased significantly（P〈0.05）.SOD and GSH in the control group compared with exacerbation and remission patients significantly increased（P〈0.05）,MDA significantly decreased（P〈0.05）.MCP-1 and MDA,SOD,GSH was significantly associated（P〈0.05）,MDC and SOD,GSH was significantly negatively correlated（P〈0.05）,Hs-CRP and MDA,SOD,GSH showed no significant correlation（P〈0.05）.Conclusion Inflammatory cytokine levels in children with bronchial asthma is closely related to the imbalance of oxidative stress,which are important factor involved in the pathogenesis of bronchial asthma.