轻度认知功能障碍及其影响因素的研究进展

Research progress of mild cognitive impairment and its influencing factors

目前,早期发现和干预仍是控制老年期痴呆的主要措施。随着对治疗方法的深入研究,正常衰老和痴呆中间的病理状态—轻度认知功能障碍(mild cognitive impairment,MCI)的提出为老年期痴呆的早期治疗和干预提供了新的靶点,其影响因素的研究也得到研究者的重视。大量研究发现,心血管疾病、吸烟、中年期肥胖、中年期高胆固醇血症、糖尿病及代谢综合征等是该疾病的主要影响因素。本文通过文献复习,对这些因素进行了综述。以期为后续研究提供参考借鉴。

Early detection and intervention are major measures to control dementia.The pathological state between normal aging and dementia,that is,a condition called mild cognitive impairment（MCI）,becomes the new target for early treatment and intervention of dementia;its influencing factors have also received much attention from researchers.Researches have found that cardiovascular diseases,smoking,middle-aged obesity,middle-aged hypercholesterolemia,diabetes and metabolic syndrome are the dominating influencing factors for the disease.Through literature review,this paper will review relevant literature and summarize these factors hoping to offer more evidence for further researches.