摘要
细胞色素P450 2C19是细胞色素P450酶家族中十分重要的一种,是在体内代谢的药物中,超过10%药物的主要代谢酶。CYP2C19具有高度的遗传多样性:不同的基因型,表型差异十分明显。CYP2C19基因多态性与多种药物的代谢以及疾病的易感性相关,本文就CYP2C19的多态性分布以及其与药物代谢和疾病易感性的研究进展加以阐述。
Cytochrome P450 2C19 is an important cytochrome P450 enzyme,and involved in more than 10%metabolism of the clinical drugs.It is a highly polymorphic gene,the expression of enzymatic activity is obvious among different genotype. CYP2C19 gene polymorphism related to the metabolism of multiple drug and susceptibility of disease.CYP2C19 polymorphism distribution was introduced in this review as well as its research progress in drug metabolism and disease susceptibility.
出处
《国外医学（医学地理分册）》
CAS
2015年第2期159-164,共6页
Foreign Medical Sciences：Section of Medgeography
基金
西藏自治区科技厅重点课题(2014)
西藏自治区重点学科
西藏高原相关疾病高校科研创新团队项目资助
