EGFR、PDGFRA和 VEGFR-2在宫颈腺鳞癌中的表达及意义

Expressions and Clinical Significances of Egfr,Pdgfra and Vegfr-2 in Squamous Cell Carcinoma of Cervix

【目的】探讨表皮生长因子受体（EGFR）、血小板源性生长因子受体α多肽（PDGFRA）和血管内皮细胞生长因子受体2（VEGFR‐2）蛋白在宫颈腺鳞癌组织中的表达及与宫颈腺鳞癌生物学行为的关系。【方法】应用免疫组化SP 法检测80例宫颈腺鳞癌和30例正常宫颈组织（对照组）中 EGFR 、PDGFRA 和 VEGFR‐2蛋白的表达。【结果】宫颈腺鳞癌组中 VEGFR‐2阳性表达率41．25％（33／80）显著低于对照组86．67％（26／30），而 PDGFRA 和 EGFR 阳性表达率分别为73．75％（59／80）、76．25％（61／80），显著高于对照组26．67％（8／30）、23．33％（7／30），其差异有统计学意义（ P ＜0．05）。 Spearman 等级相关分析表明，VEGFR‐2分别与 PDGFRA 和 EGFR 呈负相关（ r ＝－0．387，P ＝0．028；r ＝－0．426，P ＝ 0．024），而 PDGFRA 与 EGFR 呈正相关（ r ＝ 0．396，P ＝ 0．022）。 【结论】VEGFR‐2蛋白在宫颈腺鳞癌组织中表达低，而 EGFR 、PDGFRA 表达增高，联合检测对宫颈腺鳞癌患者诊治有指导意义。

[Objective] To explore the expressions and clinical significances of epidermal growth factor receptor （EGFR） , platelet‐derived growth factor receptor alpha polypeptide （PDGFRA） and vascular endothelial growth factor receptor 2 （VEG‐FR‐2） in squamous cell carcinoma of cervix .[Methods] The expressions of EGFR ,PDGFRA and VEGFR‐2 were compared by immunohistochemistry in 80 samples of squamous cell carcinoma of cervix and 30 normal samples of cervical tissue .And the correlations of EGFR ,PDGFRA and VEGFR‐2 protein expression with clinicopathological parameters and post‐operative sur‐vival were analyzed .[Results] The positive rates of EGFR ,PDGFRA and VEGFR‐2 were 76 .25% ,73 .75% and 41 .25%respectively .The expressions of EGFR and VEGFR‐2 were significantly associated with pathologic classification （ P 〈 0 .05） while PDGFRA had no correlation with pathologic classification （ P 〉 0 .05） .The expression rates of EGFR ,PDGFRA and VEGFR‐2 showed significant difference between recurrent and non‐recurrent groups （ P 〈 0 .01） .Significant negative correla‐tions existed between EGFR and VEGFR‐2 protein expressions .And there were significant positive correlations between EG ‐FR and PDGFRA protein expressions .[Conclusion] Abnormal protein expressions of EGFR ,PDGFRA and VEGFR‐2 play important roles in the development and recurrence of squamous cell carcinoma of cervix .And detecting multiple biomarkers may be useful for determining patient outcomes .