肿瘤患者血清线粒体肌酸激酶水平变化及其诊断意义研究进展

Serum mitochondrial creatine kinase levels in the diagnosis of patients with malignant tumor

线粒体肌酸激酶(Mt CK)存在于细胞内线粒体内膜和外膜间隙,属肌酸激酶同工酶系列,其主要生理作用是在有氧情况下通过磷酸肌酸穿梭机制提供肌肉收缩所需能量。近年来,很多研究发现Mt CK在肿瘤患者血清中高表达,且大多数是患有恶性肿瘤患者的血清中Mt CK呈高表达,在预后不好的病人中过表达尤其明显,推测其对恶性肿瘤的临床诊断及预后判断具有重要意义。同时,分子生物学研究认为Mt CK过表达可以使细胞在某种程度上获得一定的生长优势以抵抗调亡。

Mitochondrial creatine kinase （MtCK） located in the space between inner membrance and outer membrance of intraeenular mitochondria. Creatine kinase is a member of the creatine kinase isozyme. The mainly physiological function of MtCK is to provide the energy for muscle contraction through the creatine phosphate shuttle mechanism under aerobic condition, which plays an important role in mitochondrial respiratory control. Recently,over expression of ubiquitous MtCK （uMtCK） is found in malignant tumors with especially poor prognosis. The molecular biology mechanism of the over expression in malignant tumors is well studied and the scholars find that uMtCK might be useful in the diagnosis of malignant tumors. Meanwhile,molecular biology studies shows that over expression of uMtCK promotes malignant tumors growth though resisting apoptosis. We reviewed the role and molecular biologic mechanism of mitochondrial creatine kinase in the diagnosis of malignant tumor.