羟乙基淀粉联合阿替普酶对缺血性脑卒中患者的疗效观察

Effect of hydroxyethylstarch combined with alteplase on patients with ischemic stroke

目的探讨羟乙基淀粉联合阿替普酶对缺血性脑卒中患者的治疗作用。方法选择我院2010年4月至2014年6月收治的60例缺血性脑卒中患者作为研究对象,随机分为2组,对照组采用阿替普酶治疗,试验组在此基础上加用羟乙基淀粉治疗。比较两组患者的NIHSS评分、OPG、sTRAIL血清水平及疗效。结果治疗后,两组患者OPG和sTRAIL血清水平均有不同程度下降(P<0.05),两组治疗后OPG和sTRAIL血清水平比较差异有统计学意义(P<0.05);两组患者NIHSS评分均有不同程度下降(P<0.05),其中试验组在治疗后12 h、24 h及14 d时均低于对照组,差异有统计学意义(P<0.05)。试验组、对照组的总有效率分别为90.00%、73.33%,差异有统计学意义(P<0.05)。结论羟乙基淀粉联合阿替普酶治疗缺血性脑卒中可以显著下调血清OPG和sTRAIL水平,改善神经功能,临床治疗效果明显。

Objective To evaluate the clinical effect of hydroxyethylstarch combined with alteplase on patients with ischemic stroke. Methods 60 cases with ischemic stroke from April 2010 to June 2014 in our hospital were chosen as the experimental objects. Patients were divided into experimental group and control group. Control group was treated with alteplase,experimental group were given hydroxyethylstarch and alteplase. The levels of OPG and s TRAIL,NIHSS score,and clinical efficacy between the two groups were compared. Results After treatment,OPG and s TRAIL levels decreased in the two groups（ P〈0. 05）,and there were significant differences between the two groups（ P〈0. 05）. NIHSS score of the two groups decreased after treatment（ P〈0. 05）,and the NIHSS scores at 12 h,24 h and 14 d after treatment in experimental group were lower than those of control group（ P〈0. 05）. The effective rates of experimental group and control group were 90. 00% and 73. 33%,there was significant difference between the two groups（ P〈0. 05）. Conclusion Hydroxyethylstarch combined with alteplase can decrease OPG and s TRAIL levels and improve the nerve function of ischemic stroke patients with good clinical efficacy.