阿司匹林及氯吡格雷双联抗血小板治疗对女性月经的影响

Influence of dual anti-platelet therapy of asprin and clopidogrel on menstrual changes

目的观察女性经皮冠状动脉介入治疗(Percutaneous coronary intervention,PCI)术后全程双联抗血小板药物阿司匹林及氯吡格雷口服治疗对月经的影响。方法我院心内科2004年1月至2013年6月诊断为急性冠脉综合征且行冠状动脉支架植入术的住院绝经前女性患者,采用回顾性研究的方法观察其口服双联抗血小板药物治疗前及治疗后6个月、1年的月经情况,并采用PABC评分量表对患者的月经量进行定量评分。结果绝经前女性冠状动脉支架置入术后双联抗血小板药物阿司匹林及氯吡格雷口服治疗1年的月经量较术前无明显变化。结论绝经前女性应用双联抗血小板药物治疗1年,月经量无明显变化,是相对安全的。

Objective To observe the influence of dual anti-platelet therapy of aspirin and clopidogrel on the menstruation changes of patients after percutaneous coronary intervention. Methods Twenty-four premenopausal female patients who was diagnosed as ACS（ Acute coronary syndrome） and lined of coronary artery stent implantation in our hospital from January 2004 to June 2013 were chosen,all the patients were given dural anti-platelet therapy of aspirin and clopidogrel. The menstruation situation before treatment and at 0. 5,1 year after treatment were observed by a retrospective method,and the amount of menstruation was assessed by PABC（ pictorial blood loss assessment chart）.Results No significant difference was observed in the amount of menstruation in premenopausal female patients before surgery and after one year dual anti-platelet therapy. Conclusion The dual anti-platelet therapy for the premenopausal female patients（ lasting one year） has no obvious influence on the amount of menstruation,it is relatively safe.