精神类药物的药物基因组学研究进展与临床应用

Progress on the study and clinical application of pharmacogenomics of psychiatric drugs

目的总结归纳精神类药物的药物基因组学的研究进展,为临床个体化用药提供参考。方法以精神类药物、药物基因组学、个体化用药为关键词,通过搜索Pharm GKB、SNPedia、dbS NP等数据库,检索有关药物基因检测在精神障碍治疗中的应用的文献,并进行归纳总结。结果目前只有少数药物基因检测在治疗精神障碍中应用的证据较为充分,具有一定的临床意义,大多数基因检测还缺乏大规模的临床证据,需要进一步验证。结论药物基因组学是一门新兴学科,尚处于发展初级阶段,基因类型与药物疗效之间的关联性需要大规模的数据验证。在用于调整用药方案上,应结合其他临床指标。

Objective To summarize the research progress on pharmacogenomics of psychiatric drugs and provide references for personalized medicine in the clinic. Methods The related literatures about the application of pharmacogenomic tests in treating patients with psychiatric disease were searched from Pharm GKB,SNPedia,dbS NP database,by using ‘psychiatric drugs＇,‘pharmacogenomics＇ and ‘personalized medicine＇as the key words. Results Only a fewpharmacogenomic tests had substantial data for their application in clinic,the rests still needed large-scale clinical data validation. Conclusion Pharmacogenomics is a newdiscipline which still needs large-scale clinical data to support its application in clinic. When it is used in medication adjustment,it should be considered with other clinic indexes.