儿舒平颗粒对性早熟模型大鼠的干预作用

Intervention of Ershuping Keli on rat model with sexual precocity

目的观察儿舒平颗粒对性早熟模型大鼠的干预作用。方法 32只SD大鼠按体重随机分为空白对照组,模型对照组,儿舒平颗粒高、低剂量组。皮下注射N-甲基-DL-天冬氨酸制备大鼠真性性早熟模型。于造模同时儿舒平颗粒高、低剂量组分别给予儿舒平颗粒35.42、17.71 g生药/kg灌胃,每日1次,空白对照组、模型对照组给予去离子水灌胃。比较各组大鼠阴道口开放情况、第1个发情间期的出现时间、性器官指数及血清性激素雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)的含量。结果与模型对照组比较,儿舒平颗粒组出现阴道口开放和第1个发情间期明显延迟,性器官子宫指数、卵巢指数明显降低,差异均有统计学意义(P<0.05);血清性激素有一定的降低趋势,但差异无统计学意义(P>0.05)。结论儿舒平颗粒对性早熟模型大鼠有一定的治疗作用。

Objective To observe the intervention of Ershuping （ESP） Keli on rat model with sexual precocity. Methods 32 SD rats were randomly divided into a normal control group, a model control group, a high-dosage ESP group and a low-dosage ESP group according to the weight. The rat models with true sexual precocity were made by subcutaneously injecting N-Methyl-DL-aspartic acid. At the same time, the high-dosage and low-dosage ESP groups received 35.42 and 17.71 g/kg Ershuping Keli respectively with intragastric administration once a day. The normal control group and model control group were given deionized water with intragastric administration. The vaginal opening, the appearing time of the first Diestrus, sex organ index, and the contents of serum E2, LH and FSH were compared. Results Vaginal opening and the first Diestrus showed significantly delayed, uterus and ovary index decreased in two ESP groups, and the difference had statistic significance （ P 〈 0.05 ） ; serum sexual hormones also showed a certain decreased trend, but the difference had no statistic significance （ P 〉 0. 05 ） compared with the model group. Conclusion Ershuping Keli has certain curative effect on sexual precocity in rat model.