摘要
目的:探讨2型糖尿病患者体脂分布特点与颈动脉内膜中层厚度(IMT)、血清瘦素水平的关系。方法:选择76例2型糖尿病患者(2型糖尿病组)和34例健康体检者(对照组),测量腰围(WC)、臀围(HC)、体重(W)、全身脂肪含量(BF)、躯干脂肪含量(Tr F)、上肢脂肪含量(UF)、下肢脂肪含量(LF),并计算腰臀比(WHR)、BF%、Tr F/BF。并检测IMT、血清瘦素水平。比较两组患者上述各指标的差异,并分析体脂分布、体脂成分及血清瘦素水平于IMT的关系。结果:2型糖尿病组患者WC、WHR、BMI、BF、Tr F、UF、LF、BF%、Tr F/BF、IMT、血清瘦素水平均明显高于对照组(P<0.05);Pearson相关性分析显示,BF、Tr F、UF、LF、BF%、Tr F/BF与IMT、血清瘦素水平均呈正相关(P<0.05),血清瘦素水平与IMT呈正相关(P<0.05);多元线性回归分析显示,Tr F/BF、瘦素是IMT的独立危险因素。结论:2型糖尿病患者的体脂分布存在异常,IMT、血清瘦素水平明显升高,且两者均与脂肪分布特点密切相关。
Objective:To discuss the relationship between the characteristics of lipid body distribution and carotid artery intima-media thickness in patients with type 2 diabetic.Method:76 patients with type 2 diabetes mellitus(type 2 diabetes group) and 34 healthy subjects(control group) were enrolled in this study.WC,HC,W,BF,Tr F,UF,LF,IMT,serum leptin levels were detected,and WHR,BF%,Tr F/BF were calculated.Differences of the above indexes between the two groups were compared,and the relationship between the characteristics of lipid body distribution and carotid artery intima-media thickness on patients with type 2 diabetic were analyzed.Result:WC,WHR,BMI,BF,Tr F,UF,LF,BF%,Tr F/BF,IMT,serum leptin levels of patients with type 2 diabetes were significantly higher than those of control group(P〈0.05).Pearson correlation analysis showed that BF,Tr F,UF,LF,BF%,Tr F/BF were positively correlated with IMT,serum leptin levels(P〈0.05),serum leptin level was positively correlated with IMT(P〈0.05).Multiple regression analysis showed that Tr F/BF and leptin were the independent risk factors of IMT.Conclusion:The distribution of body fat in patients with type 2 diabetes mellitus are abnormal,IMT and leptin increase significantly,and IMT and leptin are closely related with fat distribution characteristics.
出处
《中国医学创新》
CAS
2015年第18期52-54,共3页
Medical Innovation of China
基金
广东省佛山市医学类科技攻关项目(0012954120403141)