系统性红斑狼疮患者眼表状态的临床特点

Ocular Surface Manifestations of Systemic Lupus Erythematosus Patients

目的:探讨系统性红斑狼疮(SLE)患者眼表状态的临床特点。方法:选择本院2014年4-12月住院并经风湿免疫科医生确诊为系统性红斑狼疮的患者26例作为SLE组,同时选择眼科门诊非系统性红斑狼疮患者20例作为对照组,通过角膜荧光素染色、SchimerⅠ试验及泪膜破裂时间测定比较两组眼表状态的差异。结果:SLE组BUT明显短于对照组,差异有统计学意义(t=2.673,P<0.01)。SLE组与对照组比较,泪液分泌量减少,差异有统计学意义(t=2.62,P<0.05)。SLE患者角膜荧光素染色检出率高于对照组,差异有统计学意义(u=2.46,P<0.01)。结论:系统性红斑狼疮患者容易出现眼表状态的异常改变,是干眼症的易患人群;角膜荧光素染色、SchimerⅠ试验及泪膜破裂时间有助于发现SLE患者眼表状态的异常改变。

Objective：To explore the ocular surface manifestations of systemic lupus erythematosus patients.Method：26 patients who were confirmed with systemic lupus erythematosus in our hospital from April 2014 to December 2014 were selected as the SLE group,20 patients from the ophthalmology clinic outpatient who had no systemic lupus erythematosus were selected as the control group.The ocular surface manifestations of the SLE patients was compared with that of the control group（20 cases） through cornea fluorescein staining,Schirmer test and test of tear film breaking up time.Result：Compared with the control group,the mean BUT of the SLE group was significantly shorter（t=2.62,P〈0.05）,the value of Schirmer Ⅰ test of the SLE group was significantly lower（t=2.62,P〈0.05）and the positive rate of cornea fluorescein staining of the SLE group was significantly higher.Conclusion：Patients with systemic lupus erythematosus show a tendency to have changes of ocular surface state.They are susceptible population of dry eyes.Corneal fluorescein staining,Schimer Ⅰ test and tear film breaking up time test help to find abnormal changes of ocular surface state of SLE patients.