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γ干扰素释放试验在儿童结核病和潜伏结核感染中的诊断价值 被引量:10

The diagnostic significance of interferon-gamma release assays in children with active tuberculosis and latent tuberculosis infection
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摘要 目前全球儿童结核病疫情形势严峻,诊断仍然依赖传统的检测方法。结核菌素皮肤试验对于卡介苗接种及非结核分枝杆菌感染不易鉴别。γ干扰素释放试验在国内已逐步推广,对儿童结核病的诊断有较高的敏感度和特异度。在潜伏结核感染的儿童中,结合暴露分级评价,γ干扰素释放试验特异度更高,结核菌素皮肤试验敏感度更高。使用IGRA开展人群大规模筛查并不现实,但是针对性选择高危人群进行检测确有必要。在儿童结核病诊疗领域,应当将IGRA与TST结合起来,取长补短,结合实际情况进行分析。 At present, the global situation of tuberculosis in children remains serious. The process of diagno- sis still relies on the traditional methods. The results of tuberculin skin test (TST) can not easily identify BCG vac- cination and infection with non-tuberculous mycobacteriuum Interferon-gamma release assays (IGRA) have been popularized in China, and have a relatively high sensitivity and specificity for the diagnosis of tuberculosis in chil- dren. In children with latent tuberculosis infection (LTBI), referring to the exposure classification, the specificity of interferon-gamma release assays is higher and the sensitivity of tuberculin skin test is better. Screening for latent in- fection in a very large general population with IGRA is clearly unrealistic, but it is necessary for those at a higher risk of tuberculosis development. Clinical manifestation, IGRA and TST should be combined to analysis for the diagnosis of tuberculosis in children.
作者 李锋 卢水华
出处 《中国防痨杂志》 CAS 2015年第7期732-735,共4页 Chinese Journal of Antituberculosis
关键词 干扰素γ释放试验 潜伏性结核/诊断 敏感性与特异性 儿童 Interferon-gamma release tests Latent tuberculosis/diagnosis Sensitivity and specificity Child
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参考文献16

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