大剂量氨溴索注射液对重症高血压脑出血术后患者的肺保护作用研究

Clinical study on pulmonary protective effect of large dose of ambroxol hydrochloride injection in postoperative patients with severe hypertensive intracerebral hemorrhage

目的 探讨大剂量氨溴索注射液对重症高血压脑出血术后患者的肺保护作用.方法 收集高血压脑出血手术患者160例,按随机数字表法分为常规剂量组和大剂量组,每组80例,比较两组患者疗效、氧分压、氧合指数、急性生理学和慢性健康状况Ⅱ评分、抗生素应用时间及重症监护室住院周期的变化.结果 治疗后,大剂量组较常规剂量组氧分压、氧合指数明显改善[（94.7±7.2）mmHg（1 mmHg =0.133 kPa）比（86.5±8.1） mmHg、（420.3±35.5） mmHg比（356.0±28.7） mmHg],急性生理学和慢性健康状况Ⅱ评分明显降低[（8.2±3.4）分比（11.6±3.5）分],抗生素应用时间、重症监护室住院周期明显缩短[（8.5±3.7）d比（13.4±5.8）d、（7.3±2.5）d比（9.7±5.2）d],两组比较差异有统计学意义（P＜0.05）.大剂量组总有效率明显高于常规剂量组[92.5％（74/80）比83.8％（67/80）],差异有统计学意义（P＜0.05）.结论 应用大剂量氨溴索注射液对重症高血压脑出血术后患者具有明显的肺保护作用.

Objective To study the pulmonary protective effect of large dose of ambroxol hydrochloride injection in postoperative patients with severe hypertensive intracerebral hemorrhage.Methods One hundred and sixty postoperative patients with hypertensive intracerebral hemorrhage were selected,and the patients were divided into conventional dose group and large dose group by random digits table method with 80 cases each.The therapeutic effect,partial pressure of oxygen,oxygenation index,acute physiology and chronic health evaluation Ⅱ score,antibiotic application time and hospitalization period in intensive care unit were compared between 2 groups.Results After treatment,the partial pressure of oxygen and oxygenation index in large dose group were significantly better than those in conventional dose group：（94.7 ± 7.2） mmHg （1 mmHg =0.133 kPa） vs.（86.5 ± 8.1） mmHg and （420.3 ± 35.5） mmHg vs.（356.0 ± 28.7） mmHg,the acute physiology and chronic health evaluation Ⅱ score was significantly lower than that in conventional dose group：（8.2 ± 3.4） scores vs.（11.6 ± 3.5） scores,the antibiotic application time and hospitalization period in intensive care unit were significantly shorter than those in conventional dose group：（8.5 ± 3.7） d vs.（13.4 ± 5.8） d and （7.3 ± 2.5） d vs.（9.7 ± 5.2） d,and there were statistical differences （P〈 0.05）.The total effective rate in large dose group was significantly higher than that in conventional dose group：92.5% （74/80） vs.83.8% （67/80）,and there was statistical difference （P 〈 0.05）.Conclusion The pulmonary protective effect of large dose of ambroxol hydrochloride injection is significant in postoperative patients with hypertensive intracerebral hemorrhage.