曲美他嗪对扩张型心肌病患者心房颤动发生率的影响

The influence to atrial fibrillation occurs of long -term use of trimetazidine in treatment of dilated cardiomy-opathy

目的：探讨长期服用曲美他嗪对扩张型心肌病（DCM）患者心房颤动发生率的影响。方法收集扩张型心肌病患者90例，按照数字表法随机分为观察组和对照组，每组45例。对照组患者根据其心功能情况进行常规的抗心力衰竭治疗，观察组患者在进行常规的抗心力衰竭治疗的基础上，同时口服曲美他嗪，随访6个月后，比较两组患者治疗后左室射血分数（LVEF）、左室舒张末内径（LVEDD）、心功能改善情况，以及心房颤动发生率。结果治疗后，观察组心房颤动发生率为2．27％，明显低于对照组的11．11％（χ2＝10.74， P ＜0．05）；观察组心功能改善率为95．56％，明显高于对照组的82．22％（χ2＝9．62，P ＜0．05）；观察组 LVEDD为（52±9）mm，明显低于对照组的（63±11）mm（t ＝6．83，P ＜0．05）；观察组 LVEF 为（54±7）％，明显高于对照组的（41±6）％（t ＝8．72，P ＜0．05）。结论扩张型心肌病患者长期服用曲美他嗪，可明显降低心房颤动发生率。

Objective To investigate the influence to atrial fibrillation occurs of long -term use of trimetazi-dine in treatment of dilated cardiomyopathy.Methods 90 cases with dilated cardiomyopathy （DCM）were averagely divided into the observation group and the control group according to a random number table,45 cases in each group. The patients of the control group were treated with conventional anti -heart failure according to their heart function, the patients of the observation group were given oral trimetazidine on the bases of conventional anti -heart failure. After follow -up six months,the left ventricular ejection fraction （LVEF）,left ventricular end diastolic diameter （LVEDD）,improve heart function,as well as the incidence of atrial fibrillation after treatment of two groups were compared.Results The rate of occurrence after treatment of the observation group atrial fibrillation of was 2.27%, which was significantly lower than 11.11% of the control group,the difference was statistically significant（χ2 =10.74,P 〈0.05）.The left ventricular end diastolic diameter （LVEDD）after treatment of the observation group was （52 ±9）mm,which was significantly lower than （63 ±11）mm of the control group,the difference was statistically sig-nificant（t =6.83,P 〈0.05）;The left ventricular ejection fraction （LVEF）of the observation group was （54 ±7）%, which was significantly higher than （41 ±6）% of the control group,the difference was statistically significant（t =8.72,P 〈0.05）.Conclusion Dilated cardiomyopathy patients taken long -term trimetazidine,can greatly reduce the incidence of atrial fibrillation.