慢性心力衰竭的治疗进展

The recent advances in the treatment of chronic heart failure

慢性心力衰竭(chronic heart failure,CHF)是一种极为复杂的临床综合征,是各种心脏病发展的最终阶段。目前已经证实神经内分泌过度激活所致的心肌重构是心力衰竭发生发展的病理基础,而神经内分泌抑制剂治疗可延缓或逆转心肌重构。目前心力衰竭发病率呈现上升趋势,这与人口的老龄化和各种心脏病的患病率逐年增加密切相关。近年来,随着心衰治疗水平的不断提高,新型治疗心衰药物及治疗方法不断问世,尤其是心脏再同步化治疗的出现,使心力衰竭患者的预后得到进一步的改善。因此,心力衰竭的治疗仍然是以药物治疗为基础,其地位仍然无可替代。现将慢性心力衰竭治疗的最新进展做一综述。

Chronic heart failure is a kind of extremely complex clinical syndrome, It＇ s the final stage in the development of various kinds of heart disease. Now we have confirmed that the neuroendocrine caused by excessive activation of myocardial remodeling is the pathological basis for the development of heart failure occurs,And neuroendocrine inhibitor treatment can reverse or slow down myocardial remodeling. The incidence of heart failure tend to rise, this related with the ageing of the population and various increasing prevalence of heart disease. In recent years, with the constant improvement of the treatment of heart failure, the new drug for heart failure and treatment continuously, Especially the emergence of cardiac resynchronization therapy has further improved the prognosis of patients with heart failure. So, drug is still a based therapy in heart failure treatment, its status is still irreplaceable. The following will the latest progress of chronic heart failure treatment.