膳食果糖对非酒精性脂肪肝影响的流行病学证据

Epidemiological Evidence of Dietary Fructose on Nonalcoholic Fatty Liver Disease

许多证据证明膳食对非酒精性脂肪肝的发展有明显的作用,而膳食中果糖对非酒精性脂肪肝的作用还存在争议。膳食中果糖的来源多样,包括蔗糖分解产生的果糖,天然食品及饮料中的高果糖浆。本文回顾了关于果糖与非酒精性脂肪肝关系的流行病学研究论文。尽管不能对果糖单独引起非酒精性脂肪肝或者使这种疾病恶化下结论,但患者应该减少果糖摄入,尤其是减少富含高果糖浆软饮料的摄入。软饮料不像水果一样有高营养价值,减少软饮料摄入量在降低果糖摄入总量中尤为关键。而水果中的果糖相对安全,不需要刻意减少水果的食用量。对脂肪肝患者进行膳食指导时,注重的不仅仅是膳食成分的数量,而且应该注意膳食的质量。

A lot of evidence showed that diets contribute to the development of nonalcoholic fatty liver disease （NAFLD）. However,the role of dietgtry fructose in NAFLD is still controversial. Dietary fructose comes from a number of sources,including sucrose decomposition, natural foods and high fructose corn syrup in beverages. The present review focused on relationship between fructose and NAFLD in epidemiological studies. Although we couldn＇t draw a conclusion that higher fructose led to NAFLD individually or accelerate the deterioration of this disease,NAFLD patients should reduce the intake of fructose,especially that from beverages rich in HFCS. The most important way for patients to reduced fructose intake is to reduce the intake of beverages,instead of reducing the consumption of fruit deliberately, for the fructose in it is relatively safe. In contrast, a small dose of fructose intake may have beneficial effects on health. Not only quantity of dietary components, but also quality of meals should be focused on when the doctors make dietary guidance for NAFLD patients.