中医药抑制心梗后心室重塑的实验及临床研究

Chinese medicine inhibiting ventricular remodeling after myocardial infarction

心室重塑是心肌梗死后心功能下降的重要原因,抑制心肌梗死后心室重塑是改善患者预后的重要环节。心肌重塑的机制有神经内分泌系统的过度激活,心肌细胞分子信号通路的表达异常,免疫炎症反应的失衡等。中医药可调节心肌信号通路,抑制RAAS系统及SNS系统,降低肿瘤坏死因子(TNF)、内皮素(ET)及IL-6等炎性因子。中医药单味药、中药复方及中药注射液的实验及临床研究证实中医药在抑制心室重塑方面发挥着积极有效的作用,能够改善心肌梗死患者的预后。

Ventricular remodeling after myocardial infarction is a major cause of heart failure.Inhibition of ventricular remodeling after myocardial infarction is an important part of improving the prognosis of patients.Mechanisms of myocardial remodeling include excessive activation of the neuroendocrine system,the abnormal expression of cellular and molecular signaling pathways and the imbalance in the immune and inflammatory response.Chinese medicine can regulate cardiac signaling pathways,inhibit the RAAS and SNS systems and reduce tumor necrosis factor（TNF）,endothelin（ET）and inflammatory cytokines such as IL-6.The single Chinese herb,Chinese herbal compound and traditional Chinese medicine injection have been demonstrated to play an active and effective role in the inhibition of ventricular remodeling by experimental and clinical studies.Chinese medicine can improve the prognosis of patients with myocardial infarction.