同型半胱氨酸与D二聚体在急性脑血管疾病诊断中的临床意义

The clinical significance of homocysteine and D dimer in the diagnosis of acute cerebrovascular disease

目的:探讨同型半胱氨酸(Hcy)与D二聚体(D-D)在脑血管疾病中的水平及临床意义。方法:选取69例急性脑血管病患者作为观察组,另选42例同期健康体检者作为对照组,分别检测两组Hcy与D-D水平,观察组于治疗后3d与7d时复查Hcy与D-D。结果:观察组Hcy与D-D水平均高于正常参考值,对照组两项指标均在正常范围内,两组比较差异具有统计学意义(P<0.05)。治疗后患者血清Hcy及D-D水平均呈逐渐下降趋势,治疗后3d及7d与治疗前相比各指标差异均有统计学意义(P<0.05),且治疗后7d与3d相比较差异具有统计学意义(P<0.05)。结论:检测Hcy与D-D水平对急性脑血管疾病的诊断及病情发展判定具有重要意义。

Objective： To discuss the effects of homocysteine（Hcy） and two D dimer（D-D） in cerebral vascular diseases and their clinical significance.Methods： We selected 69 cases of acute cerebral vascular disease patients as the observation group,another 42 healthy individuals as control group.Two groups of Hcy and D-D levels were detected in the observation group after treatment.3d and 7d were Hcy and D-D.Results： In the observation group,Hcy and D-D levels were higher than normal reference value.Two indexes in the control group were in normal range,with significant differences between the two groups（P〈0.05）.After treatment,serum Hcy and D-D levels were decreased,3d and 7d after treatment compared with those before treatment in all indexes had significant differences（P〈0.05）.There were statistically difference 7d after treatment compared with the 3d（P〈0.05）.Conclusion： Diagnosis and detection of Hcy and D-D level of acute cerebral vascular disease have important significance in judging the development.