非类风湿关节炎患者中类风湿关节炎相关血清标志物阳性的临床意义

Clinical significance of rheumatoid arthritis related serum markers positive in non-rheumatoid arthritis patients

目的探讨非类风湿关节炎(RA)患者中RA相关血清标志物阳性的临床意义。方法选取2012年1月至2014年6月该院收治的患者292例。其中,RA患者177例,非RA患者115例。采用酶联免疫吸附试验与免疫荧光法检测患者RA相关血清标志物的水平,包括类风湿因子(RF)、抗环瓜氨酸肽(CCP)抗体、抗RA33抗体及抗角蛋白抗体(AKA)。结果 RA组RF阳性率(78.53%)、抗CCP抗体阳性率(64.97%)、抗RA33抗体阳性率(15.82%)、AKA阳性率(19.77%)均明显高于非RA组(11.30%、1.74%、4.35%、0.87%),差异有统计学意义(P<0.05)。结论非RA患者中RA相关血清标志物阳性率低于RA,但临床上仍需仔细鉴别,才能准确诊断。

Objective To investigate the clinical significance of rheumatoid arthritis（RA）related serum markers positive in non-RA patients.Methods 292 patients in our hospital from January 2012 to June 2014 were seelcted,including 177 cases of RA and 115 cases of non-RA patients.All patients were detected the RA related serum markers levels by ELISA and immunofluorescence assay,including RF,anti-CCP antibodies,anti-RA33 antibodies and AKA.Results In the RA group,the positive rates of RF,anti-CCP antibody,anti-RA33 antibody and AKA were78.53%,64.97%,15.82% and 19.77% respectively,which were significantly higher than were significantly higher than 11.30%,1.74%,4.35% and 0.87% in the non-RA group,the differences were statistically significant（P〈0.05）.Conclusion The RA related serum markers positive rate in the non-RA patients is lower than that in RA patients,but which still need to carefully identify in clinic in order to accurately diagnose.