摘要
目的对牙周炎患者行Foxp3-3279基因分型,探讨Foxp3-3279基因与牙周炎遗传易感性的相关性。方法应用PCR-SSP技术为50例无亲缘关系的牙周炎患者和103例无血缘关系的健康汉族人行Foxp3-3279基因分型。结果 Foxp3-3279位点CC、CA、AA三种基因型频率在牙周炎患者中分别为74%,24%和2%;在正常对照中分别为72.82%,24.27%和2.91%。Foxp3-3279位点各基因型和等位基因在牙周炎患者和正常对照组中无显著性差异(p>0.05)。结论 Foxp3-3279位点基因多态性与牙周炎无显著相关。
Objective To explore the correlations between Foxp3 -3279 polymorphisms and genetic susceptibility to periodontitis by Foxp3 -3279 genotyping. Methods 103 unrelated healthy Han Chinese and 50 unrelated patients with periodontitis received genotyping of Foxp3 - 3279 by PCR - SSP. Results Genotype frequencies of Foxp3 - 3279 CC, CA and AA were respectively 74%, 24% and 2% in patients with periodontitis, while they were 72.82% , 24.27% and 2.91% in the normal control group. There were no significant differences in Foxp3 -3279 genotypes and alleles between the periodontitis group and the control group （p 〉 0.05 ）. Conclusion Foxp3 -3279 polymorphisms has no significant relationship with periodontitis.
出处
《现代医院》
2015年第7期10-12,共3页
Modern Hospitals
基金
广东省科技计划项目(2010B031600139)
广州市番禺区科技和信息化局科技计划项目(2012-Z-03-61)
