交泰丸对PCPA大鼠失眠模型镇静催眠的效果研究

SEDATION AND HYPNOSIS EFFECT OF JIAOTAI PILLS ON RAT INSOMNIA IN PCPA RAT MODEL

目的探讨交泰丸镇静催眠的药效。方法建立PCPA(对氯苯丙胺酸)大鼠失眠模型,将动物分组,分为模型组、交泰丸高、中、低剂量组及地西泮阳性对照,采用高效液相检测方法,观察交泰丸对失眠模型失眠状态(失眠状态观察什么?)及下丘脑中枢神经递质5-HT及GABA的影响。结果交泰丸滴丸高、中剂量及地西泮组与模型组相比,大鼠失眠状态及均中枢神经递质5-HT均有显著性差异,但交泰丸高、中剂量组与模型组相比,中枢神经递质GABA无显著性差异。结论交泰丸滴丸具有镇静催眠药效,其作用机理可能与影响中枢神递经质5-HT有关,与中枢神经递质GABA关系不明显,本研究对进一步开发交泰丸具有重要意义。

Objective To discuss the sedative and hypnotic effect of Jiaotai Pills on insomnia in PCPA rat model. Methods The PCPA （PCPA acid） rats insomnia model was established, and the rats were divided into the model group, high, middle and low dosage of Jiaotai Pills group, and diazepam positive control group. The high performance liquid detective method was adopted to observe the effect of Jiaotai Pills on rat insomnia and hypothalamus neurotransmitters 5 - HT and GABA. Results Compared with the model group, there existed significant difference in the insomnia state of rats and the central neurotransmitters 5 - HT in the high and middle dosages of Jiaotai Pill group and diazepam group. However, in the comparison of the high and middle dosages of Jiaotai Pill group and the model group, there was no significant difference in GABA in the central nervous system. Conclusion Jiaotai Pills has sedative and hypnotic efficacy. Its mechanism may be related to the effects of central neurotransmitter 5 - HT. Its relationship with GABA in the central nervous system is not obvious. The research has significant influence on the further development of Jiaotai Pills.