连云港市手足口病重症病例危险因素分析

HFMD severe cases' risk factors analyses of Lianyungang city

目的探讨连云港市手足口病重症病例危险因素。方法根据《中国疾病预防控制信息系统》选取1 535例手足口病临床普通病例作为对照组,151例临床重症病例为病例组,并进行面对面调查。结果经单因素Logistic回归分析,最初诊断结果、口腔溃疡、流涕、呕吐、嗜睡、精神异常、惊厥、肠道病毒71型(Human enterovirus 71,EV71)、柯萨奇病毒A16型(Coxsackie virus A16,CA16)阳性9个因素差异有统计学意义(P<0.05),多因素Logistic回归分析,精神异常、嗜睡、惊厥、流涕、EV 71是手足口病重症的危险因素。结论提高首诊医生的早期诊断水平,加强手足口病病原学监测及重症危险因素的早期监测,可以降低重症病例的发生率。

Objective To analysis the epidemic of HFMD severe cases＇risk factors for providing the scientific ev- idences for preventing the HFMD serve cases. Methods 151 HFMD sever cases were singled out as cases group, and 1535 HFMD light cases were singled out as control group. Logistic analysis was used to analyze HFMD cases＂ risk factors. Results Single - factor analysis showed that the primary diagnosis, dental ulcer, running nose, vomiting, drowsiness, mental disorder, convulsions, EV71 and CA16 were the significant risk factor （ P 〈 O. 05） . Multi - factors logistic analysis showed that mental disorder, drowsiness, convulsions, running nose and EVT1 were the significant risk factor which could cause HFMD severe cases. Conclusions It was necessary to boost the capabilities of the early diagnosing the HFMD cases and the early detecting the risk factors for reducing the HFMD serve cases and mortality.