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卡前列素氨丁三醇预防前置胎盘产后出血的临床疗效 被引量:3

Clinical effect of carboprost tromethamine injection in the prevention of the postpartum hemorrhage of placenta previa
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摘要 目的:比较卡前列素氨丁三醇与缩宫素治疗前置胎盘产后出血的疗效。方法:选择2012年12月-2014年8月前置胎盘产妇86例,随机分为缩宫素组29例、治疗组(卡前列素氨丁三醇)30例,联合组27例。术中缩宫素组给予缩宫素20 u,治疗组给予卡前列素氨丁三醇250μg,联合组给予缩宫素20 u和卡前列素氨丁三醇250μg,观察产后2 h、24 h出血量、产后出血发生率、止血时间、输血率及并发症等。结果:治疗组和联合组的术后出血率、输血率、术后2 h和24 h出血量、止血时间、子宫切除发生率明显低于缩宫素组(P<0.05或P<0.01),但治疗组与联合组间差异无统计学意义(P>0.05)。结论:卡前列素氨丁三醇能有效减少前置胎盘产后出血量、产后出血发生率、止血时间、输血率、子宫切除率,不良反应少,与缩宫素合用效果更好。 Objective: To compare the treatment effect of carboprost tromethamine injection and oxytocin in the treatment of the postpartum hemorrhage of placenta previa. Methods: Eighty-six cases of the pregnant women with placenta previa were selected from Dec. 2012 to Aug 2014 and randomly divided into an oxytocin group with 29 cases, a treatment group(carboprost tromethamine injection) with 30 ones, and a combined group with 27 ones. In the operation, the oxytocin group was given oxytocin 20 u, the treatment group given the carboprost tromethamine injection 250 μg, and the combined group given oxytocin 20 u and carboprost tromethamine injection 250 μg. The 2 h and 24 h postpartum hemorrhage volume, the incidence of the postpartum hemorrhage, hemostasis time, blood transfusion rate and complications were observed. Results: The postoperative bleeding rate, blood transfusion rate, amount of bleeding after 2 and 24 hours operation, hemostasis time, hysterectomy incidence in the treatment group and the combined group were significantly lower than those in the oxytocin group(P〈0.05 or P〈0.01), but the difference between the treatment group and the combination one had no significant difference(P〉0.05). Conclusion:Carboprost tromethamine injection can effectively reduce the postpartum hemorrhage of placenta previa, the incidence of postpartum hemorrhage, hemostasis time, blood transfusion rate, uterine resection rate, and has less adverse reaction and better effect if combined with oxytocin.
作者 李智卿
出处 《上海医药》 CAS 2015年第12期20-21,24,共3页 Shanghai Medical & Pharmaceutical Journal
关键词 前置胎盘 产后出血 卡前列素氨丁三醇 placenta previa postpartum hemorrhage carboprost carboprost tromethamine injection
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