不同分期的慢性肾病并发细菌性肺炎的患者降钙素原的表达差异分析

The Analysis of Difference Expression of Procalcitonin in Patients with Different Stages of Chronic Kidney Disease Complicating with Bacterial Pneumonia

目的比较慢性肾病(chronic kidney disease,CKD)并发细菌性肺炎患者(bacterial pneumonia,BP)﹑BP患者以及CKD患者的降钙素(procalcitonin,PCT)表达差异,探讨CKD患者的PCT的基础水平及CKD病程对PCT表达水平的影响。方法回顾性分析并比较CKD、BP、CKD并发BP患者PCT的表达水平,不同慢性肾衰竭分期合并细菌性肺炎患者PCT的表达差异。结果 CKD并发BP组与BP组感染细菌类型差异无统计学意义(P>0.05)。CKD并发BP患者﹑CKD﹑BP患者血清PCT表达差异明显,且明显高于PCT对于细菌感染的阳性临界值0.1ng/m L。CKD并发BP组与CKD组中的组内PCT表达差异有统计学意义(P<0.01)。CKD并发BP组中,CKD2期后PCT的表达水平存在差异,且在CKD5期表达量最高,CKD组有相同的表现。结论 CKD对于PCT表达有一定影响;CKD在合并BP时,既往的PCT诊断细菌感染的临界值需要适当的考虑上调,避免过度使用抗生素。

Objective By according to comparing the difference expression of PCT（ procalcitonin） in chronic kidney dis-ease（ chronic kidney disease,CKD） in patients complicating with bacterial pneumonia（ bacterial pneumonia,BP） ,BP patients,and CKD patients,exploring the basal level of CKD and affecting of CKD on PCT. Methods By virture of retrospective analysis,found the the expression of PCT in CKD,BP,the expression level of CKD in patients with BP complicated with fine PCT,chronic renal failure complicated with different stages of differential expression of bacterial pneumonia in patients with PCT. Results Chronic nephropathy groupbacterial pneumonia group and bacterial pneumonia in patients with bacterial infection type difference is found, nodifference（ P〉0. 05 ）; patients with chronic nephropathy complicating bacterial pneumonia, chronic kidney disease, bacterial pneumonia patients serum PCT expression is obviously different,and significantly higher than that of PCT for positive critical value of 0. 1ng/ml bacteriainfection. The expression of PCT 3 CDK compliacting with bacterial pneumonia in patients with chronic ne-phropathy group within the groupdifferences are significant （ P〈0. 01 ） . Chronic nephropathy group bacterial pneumonia group, there are differences in the expression level of PCT CKD2period,and the highest expression level in the CKD5 period,chronicne-phropathy group have the same performance. Conclusion Chronic kidney disease on the expression of PCT had a certain influ-ence;chronic kidney disease in patients with bacterial pneumonia,previousPCT diagnosis of bacterial infection of the critical value of the need for appropriate consider raising,avoid excessive use of antibiotics.