解放军第四一一医院住院病人质子泵抑制剂使用的评价与分析

Evaluation and analysis of the medication of proton pump inhibitors in the patients admitted into No.411 Hospital of PLA

目的:了解解放军第四一一医院住院病人质子泵抑制剂(proton pump inhibitors,PPIs)用药情况,促进临床合理用药。方法:利用医院信息管理系统(HIS),对2011年7月至2014年6月期间所有应用PPIs的住院病人病历进行回顾性分析。从用药适应证、用法用量和药物相互作用等方面进行合理性评判,合理性标准为药品说明书、PPIs临床应用指南。结果:该院住院病人应用PPIs的病历为14 878份,占全部病例的26.68%。应用PPIs比例较高的科室是消化内科7543份(50.70%)、烧伤整形科7412份(49.82%)。在随机抽查的527份病历中,发现不合理用药情况为:用药指征不合理占23.60%、使用疗程不合理占13.15%、用法用量不合理占33.85%、相互作用不合理占29.40%。结论:该院住院病人应用PPIs存在过度使用情况,临床选用仍应该慎重考虑,合理应用。

Objective：To investigate the medication of proton pump inhibitors（PPIs）in the patients admitted into No.411 Hospital of PLA,so as to promote rational use of PPIs clinically.Methods：Retrospective analyses were made on the medical histories of the patients admitted into the hospital for treatment from July 2011 to June 2014,by using the Hospital Information System（HIS）.The rationality was analyzed by taking into consideration the indications,dosage and administration,and drug interactions.The criteria for judging rationality included packaged insert of product and standard therapeutic guidance for PPIs.Results：There were 14 878 PPI medical histories,accounting for 26.68% of all the medical histories in the hospital.The Gastroenterology Department（7543medical histories）and the Burns and Plastic Surgery Department（7412medical histories）had relatively high PPI consumption rates,accounting for 50.70% and 49.82%,respectively.In the 527 medical histories sampled at random,irrational medications of PPIs were：irrational drug indications（accounting for 23.60%）,irrational treatment courses（accounting for 13.15%）,irrational dosage and administration（accounting for 33.85%）and irrational drug interaction（accounting for 29.40%）.Conclusion：There existed irrational utilization of PPIs in the inpatients of the hospital.A prudent policy should be adopted in the clinical utilization of PPIs and be sure to use them rationally.