肾综合征出血热患者血清C反应蛋白测定的临床意义

Clinical significance of C reactive protein in haemorrhagic fever with renal syndrome

目的探讨C反应蛋白(CRP)在肾综合征出血热(HFRS)的诊断意义。方法收集96例各病期HFRS患者血清,以30例发热待查患者(发热待查组)及30例体检健康者(健康对照组)为对照,测定血清CRP、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、乳酸脱氢酶(LDH)、肌酐(Cr)水平。结果各病期HFRS患者CRP水平均低于发热待查组,差异均有统计学意义(P<0.05);CRP在HFRS患者各病期的变化趋势与AST、CK、LDH、Cr基本一致。结论 CRP对鉴别HFRS与普通发热待查有重要临床意义。

Objective To explore the diagnostic significance of C reactive protein（CRP）in diagnosing haemorrhagic fever with renal syndrome（HFRS）.Methods 96 cases of patients with HFRS of different stages were enrolled in this study,and serum speci-men were collected.30 cases of patients with fever of unknown origin（fever of unknown origin group）and and 30 healthy individu-als（healthy control）were selected as control.Serum levels of CRP,alanine aminotransferase（ALT）,aspartate amino-transferase （AST）,creatine phosphokinase（CK）,lactate dehydrogenase（LDH）and creatinine（Cr）were detected.Results Serum levels of CRP in patients with HFRS of different stages were lower than that in the fever of unknown origin group,had statistically significant differences（P 〈0.05）.The variation trend of CRP in each stage of HFRS was consistent with the trend of AST,CK,LDH and Cr. Conclusion CRP has clinical significance in differentiating HFRS from fever of unknown origin.