郴州地区住院新生儿高胆红素血症临床特点及病因构成分析

Analysis of clinical characteristics and etiology of inpatients with neonatal hyperbilirubinemia in Chenzhou area

目的分析郴州地区住院新生儿高胆红素血症的临床特点及病因构成。方法选取2012年1~12月该院新生儿高胆素血症患儿534例,收集一般临床资料,检测总胆红素水平、人巨细胞病毒（HCMV）基因、6-磷酸葡萄糖脱氢酶（G-6PD）的酶活性,筛查新生儿溶血病,并进行统计分析。结果新生儿高胆素血症患儿中G-6PD酶缺乏症患儿43例,占8.0%;ABO溶血病患儿98例,占18.4%;HCMV感染患儿153例,占28.6%;细菌感染患儿149例,占27.9%。结论该地区新生儿高胆红素血症患儿病因以感染性因素为主,加强患儿胆红素水平监测,并对检验结果和病因进行分析,可有效预防和降低高胆红素血症对新生儿的损害。

Objective To analyse clinical characteristics and etiology of inpatients with neonatal hyperbilirubinemia in Chenzhou area.Methods A total of 534 cases of inpatients with neonatal hyperbilirubinemia in Children′s Hospital,First People′s Hospital of Chenzhou City were selected from January to December 2012 and their clinical data were collected.The levels of total bilirubin,hu-man cytomegalovirus （HCMV）gene,and enzymatic activity of glucose-6-phos-phate dehydrogenase （G-6PD）were detected.And screening of hemolytic disease of newborn was carried out as well.Data were statistically analysed.Results Among these patients with neonatal hyperbilirubinemia,43 cases of neonatal patients were diagnosed with G-6PD deficiency（accounted for 8.0%）,98 ca-ses of neonatal patients were diagnosed with ABO hemolytic disease（accounted for 18.4%）,1 53 cases of neonatal patients were di-agnosed with HCMV infection（accounted for 28.6%）and 149 cases of neonatal patients were diagnosed with bacterial infections （accounted for 27.9%）.Conclusion The main etiology of patients with neonatal hyperbilirubinemia in this area is infectious factor. Strengthening monitoring bilirubin in neonatal patients,and analysing test results and etiology could effectively reduce damages in-duced by neonatal hyperbilirubinemia.