摘要
TWIST1是一种进化上高度保守的碱性螺旋-环-螺旋(b HLH)转录因子,其功能主要是控制和调节原肠胚形成及中胚叶发育。最初认为TWIST1主要与胚胎发育有关,但之后更多的研究发现TWIST1在调节组织稳态及炎症过程中发挥重要作用。近年来研究发现,TWIST1通过调节上皮间质转化(EMT)参与肿瘤转移。本文主要介绍TWIST1的功能以及在肿瘤尤其是卵巢癌发生与发展中的作用。
The transcription factor TWIST1 is a highly evolutionally conserved basic helix-loop-helix （bHLH） transcription factor that functions as a master regulator of gastrulation and mesodermal development. Although TWIST1 was initially associated with embryo development, an increasing number of studies have shown TWIST1 role in the regulation of tissue homeostasis, primarily as a regulator of inflammation. More recently, TWIST1 has been found to be involved in the process of tumor metastasis through the regulation of epithelial mesenchymal transition （EMT）. The objective of this review was to examine the normal functions of TWIST1 and its role in tumor development, with a particular focus on ovarian cancer.
出处
《中华临床医师杂志（电子版）》
CAS
2015年第12期94-99,共6页
Chinese Journal of Clinicians(Electronic Edition)
基金
山东省医药卫生科技发展计划资助项目(2007HW020)
关键词
卵巢肿瘤
肿瘤转移
TWIST1
卵巢癌干细胞
上皮间质转化
化疗抵抗
Ovarian neoplasms
Neoplasm metastasis
TWIST1
Ovarian cancer stem cells
Epithelial mesenchymal transition
Chemoresistance
